Non-Coding Genome
Head: Lukáš Trantírek
Brno node
HOME INSTITUTION
CEITEC MU
RESEARCH PROGRAMME(S)
RP 1 - Molecular basis of cancer and molecular targets
RP 3 - Biomarkers of cancers and cancer diagnostics
No applications without basic research.
Development of alternative therapeutic approaches to inhibit receptor tyrosine kinases responsible for cell signaling disorders leading to a wide range of diseases including cancer. This goal is part of a project led by the group of Dr. P. Krejčí at the Faculty of Medicine of the Masaryk University. Our laboratory focuses on the development of inhibitors based on DNA aptamer technology.
One of the other parts of our research is the study of the structural behavior of single-stranded DNA fragments occurring in blood plasma. The aim of this part of the project is to find new principles for cancer diagnosis.
SELECTED PUBLICATIONS
- Pipier A, Chetot T, Kalamatianou A, Martin N, Caroff M, Britton S, Chéron N, Trantírek L, Granzhan A, Monchaud D. Structural Optimization of Azacryptands for Targeting Three-Way DNA Junctions. Angew Chem Int Ed Engl. 2024 14:e202409780. DOI: 10.1002/anie.202409780
- Víšková P, Ištvánková E, Ryneš J, Džatko Š, Loja T, Živković ML, Rigo R, El-Khoury R, Serrano-Chacón I, Damha MJ, González C, Mergny JL, Foldynová-Trantírková S, Trantírek L. In-cell NMR suggests that DNA i-motif levels are strongly depleted in living human cells. Nat Commun. 2024 15(1):1992. DOI: 10.1038/s41467-024-46221-y
- Luo Y, Živković ML, Wang J, Ryneš J, Foldynová-Trantírková S, Trantírek L, Verga D, Mergny JL. A sodium/potassium switch for G4-prone G/C-rich sequences. Nucleic Acids Res. 2024 52(1):448-461. DOI: 10.1093/nar/gkad1073
SPECIALIZED EXPERTISE AND TECHNOLOGY
Biomolecular and in-cell NMR spectroscopy