Renata Veselská

Laboratory of Tumor Biology

Head: Renata Veselská
Brno node

veselska@mail.muni.cz
website of the Institute

HOME INSTITUTION

Faculty of Science MU

RESEARCH PROGRAMME(S)

RP 1 - Molecular basis of cancer and molecular targets
RP 2 - Research and development of anticancer pharmaceuticals and therapeutic methods

Even for tumor biology, a child is not a miniature adult...

FOCUS OF RESEARCH
SELECTED PUBLICATIONS
EXPERTISE AND TECHNOLOGY
COLLABORATION WITHIN THE NICR
COLLABORATION WITH INFRASTRUCTURES
  • Mission: To elucidate the molecular and cellular mechanisms that lead to the development of resistant solid tumors in children.  
  • Vision: To use the knowledge of the pathogenesis of pediatric tumors to refine the diagnosis or prognosis and to select a precise treatment that is targeted to the specific tumor.

LTB focuses on solid tumour research, especially in childhood. All our research activities are closely linked to clinical applications – our main goal is to characterize the biological properties of tumors that are linked to the process of oncogenesis at the cellular and molecular level. Knowledge of these mechanisms of tumorigenesis can then help clinicians refine the diagnosis or prognosis of a particular disease, thereby enabling the selection of the most appropriate treatment for each patient.

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SELECTED PUBLICATIONS
  • Borankova K, Krchniakova M, Leck LYW, Kubistova A, Neradil J, Jansson PJ, Hogarty MD, Skoda J. Mitoribosomal synthetic lethality overcomes multidrug resistance in MYC-driven neuroblastoma. Cell Death Dis. 2023;14(11):747. DOI: 10.1038/s41419-023-06278-x
  • Kameneva P, Melnikova VI, Kastriti ME, Kurtova A, Kryukov E, Murtazina A, Faure L, Poverennaya I, Artemov AV, Kalinina TS, Kudryashov NV, Bader M, Skoda J, Chlapek P, Curylova L, Sourada L, Neradil J, Tesarova M, Pasqualetti M, Gaspar P, Yakushov VD, Sheftel BI, Zikmund T, Kaiser J, Fried K, Alenina N, Voronezhskaya EE, Adameyko I. Serotonin limits generation of chromaffin cells during adrenal organ development. Nat Commun. 2022 May 25;13(1):2901. DOI: 10.1038/s41467-022-30438-w
  • Çoku J, Booth DM, Skoda J, Pedrotty MC, Vogel J, Liu K, Vu A, Carpenter EL, Ye JC, Chen MA, Dunbar P, Scadden E, Yun TD, Nakamaru-Ogiso E, Area-Gomez E, Li Y, Goldsmith KC, Reynolds CP, Hajnoczky G, Hogarty MD. Reduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance. EMBO J. 2022 Apr 19;41(8):e108272. DOI: 10.15252/embj.2021108272
  • Ramos H, Soares MIL, Silva J, Raimundo L, Calheiros J, Gomes C, Reis F, Monteiro FA, Nunes C, Reis S, Bosco B, Piazza S, Domingues L, Chlapek P, Vlcek P, Fabian P, Rajado AT, Carvalho ATP, Veselska R, Inga A, Pinho E Melo TMVD, Saraiva L. A selective p53 activator and anticancer agent to improve colorectal cancer therapy. Cell Rep. 2021 Apr 13;35(2):108982. DOI: 10.1016/j.celrep.2021.108982
  • Skoda J, Neradil J, Staniczkova Zambo I, Nunukova A, Macsek P, Borankova K, Dobrotkova V, Nemec P, Sterba J, Veselska R. Serial Xenotransplantation in NSG Mice Promotes a Hybrid Epithelial/Mesenchymal Gene Expression Signature and Stemness in Rhabdomyosarcoma Cells. Cancers (Basel). 2020 Jan 13;12(1):196. DOI: 10.3390/cancers12010196
COLLABORATION WITHIN THE NICR

Jaroslav Štěrba
(Brno node, Faculty of Medicine MU)

Ondřej Slabý
(Brno node, Faculty of Medicine MU/CEITEC MU)

Petr Beneš
(Brno node, Faculty of Science MU)

SPECIALIZED EXPERTISE AND TECHNOLOGY

Unique biobank of cell lines derived from pediatric solid tumors

Portfolio of molecular and cell biology methods, functional assays, 2D and 3D cultures, and animal models 

Advanced microscopy techniques, live-cell imaging, flow cytometry

COLLABORATION WITH LARGE RESEARCH INFRASTRUCTURES AND RESEARCH CENTRES

International Clinical Research Center FNUSA-ICRC

Central European Institute of Technology at Masaryk University CEITEC MU 

National infrastructure for biological and biomedical imaging Czech-Bioimaging