Laboratory of Cell Differentiation
Head: Petr Beneš
Brno node
HOME INSTITUTION
Faculty of Science MU
RESEARCH PROGRAMME(S)
RP 1 - Molecular basis of cancer and molecular targets
RP 2 - Research and development of anticancer pharmaceuticals and therapeutic methods
In order to treat tumours effectively, we must first get to know them perfectly.
- Mission: Identification and validation of prognostic and therapeutic targets in solid cancers.
The tumor microenvironment, composed of malignant and stromal cells has become recognized as a key factor affecting tumor growth and progression. Stromal and other non-malignant cells create microenvironment supporting tumor growth, metastasis and resistance to therapy.
SELECTED PUBLICATIONS
- van Gogh M, Glaus Garzon JF, Sahin D, Knopfova L, Benes P, Boyman O, Jurisica I, Borsig L. Tumor cell-intrinsic c-Myb upregulation stimulates antitumor immunity in a murine colorectal cancer model. Cancer Immunol Res 2023;11:1432-1444. DOI: 10.1158/2326-6066.CIR-22-0912
- Hendrych M, Říhová K, Adamová B, Hradil V, Stiborek M, Vlček P, Hermanová M, Vašíčková J, Beneš P, Šmarda J, Kanický V, Preisler J, Navrátilová J. Disulfiram increases the efficiency of 5-fluorouracil in organotypic cultures of colorectal carcinoma. Biomedicine & Pharmacotherapy. 2022;153:113465. DOI: 10.1016/j.biopha.2022.113465
- Říhová K, Dúcka M, Zambo IS, Vymětalová L, Šrámek M, Trčka F, Verner J, Drápela S, Fedr R, Suchánková T, Pavlatovská B, Ondroušková E, Kubelková I, Zapletalová D, Tuček Š, Múdry P, Krákorová DA, Knopfová L, Šmarda J, Souček K, Borsig L, Beneš P. Transcription factor c-Myb: novel prognostic factor in osteosarcoma. Clin Exp Metastasis. 2022;39:375-390. DOI: 10.1007/s10585-021-10145-4
- Machálková M, Pavlatovská B, Michálek J, Pruška A, Štěpka K, Nečasová T, Radaszkiewicz KA, Kozubek M, Šmarda J, Preisler J, Navrátilová J. Drug Penetration Analysis in 3D Cell Cultures Usin Fiducal-Based Semiautomatic Coregistration of MALDI MSI and Immunofluorescence Images. Anal Chem. 2019;91:13475-13484. DOI: 10.1021/acs.analchem.9b02462
- Knopfová L, Biglieri E, Volodko N, Masařík M, Hermanová M, Glaus Garzón JF, Dúcka M, Kučírková T, Souček K, Šmarda J, Beneš P, Borsig L. Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding. Oncogene. 2018;37:1020-1030. DOI: 10.1038/onc.2017.392
SPECIALIZED EXPERTISE AND TECHNOLOGY
Complex molecular biology, biochemical and microscopic analyses of 2D and 3D tumor models
CRISPR/Cas9 genome editing
Co-cultivation of tumor and bacterial cells and their molecular biology and biochemical analyses
Single-cell analysis by flow cytometry
COLLABORATION WITH LARGE RESEARCH INFRASTRUCTURES AND RESEARCH CENTRES
National infrastructure for biological and biomedical imaging Czech-Bioimaging
Central European Institute of Technology at Masaryk University CEITEC MU
National infrastructure for translational medicine EATRIS-CZ