Markéta Bocková

Optical Biosensors

Optical biosensors for modern medical diagnostics!

  • Mission: Research of new biophotonic tools for the study and quantification of molecular targets in medical diagnostics
  • Vision: Advanced optical affinity biosensors that enable rapid and sensitive detection of molecular biomarkers and deepen understanding of biomolecules and their interactions related to disease onset and development

Understanding oncological diseases at the molecular and cellular level represents a significant challenge with implications for the development of new drugs or new diagnostic and therapeutic tools. We pursue research of plasmonic affinity biosensors that represent a promising technology for the detection of biomolecules and the investigation of biomolecular interactions. 

SELECTED PUBLICATIONS
  • Chrastinová, O. Pastva, M. Bocková, H. Kovářová, E. Ceznerová, R. Kotlín, P. Pecherková, J. Štikarová, A. Hlaváčková, M. Havlíček, J. Válka, J. Homola & J. Suttnar: Linking aberrant glycosylation of plasma glycoproteins with progression of myelodysplastic syndromes: a study based on plasmonic biosensor and lectin array, Scientific Reports volume 13, Article number: 12816 (2023). DOI: 10.1038/s41598-023-39927-4
  • Slabý J, Bocková M, Homola J. Plasmonic biosensor based on a gold nanostripe array for detection of microRNA related to myelodysplastic syndromes. Sensors and Actuators B: Chemical. 2021;130629. DOI: 10.1016/j.snb.2021.130629
  • Špringer, Z. Krejčík, J. Homola: Detecting attomolar concentrations of microRNA related to myelodysplastic syndromes in blood plasma using a novel sandwich assay with nanoparticle release, Biosensors and Bioelectronics 194, 113613 (2021). DOI: 10.1016/j.bios.2021.113613
  • Vaisocherová H, Šípová H, Víšová I, Bocková M, Špringer T, Ermini ML, Song X, Krejčík Z, Chrastinová L, Pastva O, Pimková K, Dostálová Merkerová M, Dyr JE, Homola J. Rapid and sensitive detection of multiple microRNAs in cell lysate by low-fouling surface plasmon resonance biosensor. Biosens Bioelectron. 2015;70:226-31. DOI: 10.1016/j.bios.2015.03.038
SPECIALIZED EXPERTISE AND TECHNOLOGY

Plasmonics affinity biosensors

Nano/microfabrication technologies 

Instrumentation for deposition of thin layers

COLLABORATION WITH LARGE RESEARCH INFRASTRUCTURES AND RESEARCH CENTRES

Network of Czech Biobanks BBMRI.cz