Milan Jakubek

Laboratory of Medicinal Chemistry

Head: Milan Jakubek
Prague node

milan.jakubek@lf1.cuni.cz
website of the Institute

HOME INSTITUTION

First Faculty of Medicine CU

RESEARCH PROGRAMME(S)

RP 3 - Biomarkers of cancers and cancer diagnostics

Today’s research, tomorrow’s cure!

COLLABORATION WITH INFRASTRUCTURES

Mission: Develop innovative therapeutic and diagnostic compounds for the treatment of cancer.

The aim of the group is to identify new treatment goals and design, preparation, characterization and verification of novel unique structural motifs for targeted anticancer therapy and diagnosis. We focus on new pharmacophores based on polymethinium salts (PMS), chelators or hybrid molecules with cytostatic and migrastatic properties (CyMi). The Laboratory of Medicinal Chemistry focuses on the design and synthesis of new diagnostically and therapeutically relevant biologically active organic molecules and nanomaterials for the diagnosis and treatment of various diseases.

SELECTED PUBLICATIONS

Jakubek M, Kejík Z, Kaplánek R, Antonyová V, Hromádka R, Šandriková V, Sýkora D, Martásek P, Král V. Hydrazones as novel epigenetic modulators: Correlation between TET 1 protein inhibition activity and their iron(II) binding ability. Bioorg Chem. 2019 Jul;88:102809. DOI: 10.1016/j.bioorg.2019.02.034

Antonyová V, Kejík Z, Brogyanyi T, Kaplánek R, Veselá K, Abramenko N, Ocelka T, Masařík M, Matkowski A, Gburek J, Abel R, Goede A, Preissner R, Novotný P, Jakubek M. Non-psychotropic cannabinoids as inhibitors of TET1 protein. Bioorg Chem. 2022 Jul;124:105793. DOI: 10.1016/j.bioorg.2022.105793

Fialova JL, Hönigova K, Raudenska M, Miksatkova L, Zobalova R, Navratil J, Šmigová J, Moturu TR, Vicar T, Balvan J, Vesela K, Abramenko N, Kejik Z, Kaplanek R, Gumulec J, Rosel D, Martasek P, Brábek J, Jakubek M, Neuzil J, Masarik M. Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration. Biomed Pharmacother. 2022 Oct;154:113582. DOI: 10.1016/j.biopha.2022.113582

Jakubek M, Kejík Z, Kaplánek R, Hromádka R, Šandriková V, Sýkora D, Antonyová V, Urban M, Dytrych P, Mikula I, Martásek P, Král V. Strategy for improved therapeutic efficiency of curcumin in the treatment of gastric cancer. Biomed Pharmacother. 2019 Oct;118:109278. DOI: 10.1016/j.biopha.2019.109278
Brogyányi T, Kaplánek R, Kejík Z, Hosnedlová B, Antonyová V, Abramenko N, Veselá K, Martásek P, Vokurka M, Richardson DR, Jakubek M. Azulene hydrazide-hydrazones for selective targeting of pancreatic cancer cells. Biomed Pharmacother. 2022 Nov;155:113736. DOI: 10.1016/j.biopha.2022.113736