Vladimír Kořínek

Laboratory of Cell and Developmental Biology (LCDB)

Head: Vladimír Kořínek
Prague node

korinek@img.cas.cz
website of the Institute

HOME INSTITUTION

Institute of Molecular Genetics of the Czech Academy of Sciences

RESEARCH PROGRAMME(S)

RP 1 - Molecular basis of cancer and molecular targets
RP 3 - Biomarkers of cancers and cancer diagnostics

We uncover the molecular and genetic basis of intestinal and blood cancer cells.

COLLABORATION WITH INFRASTRUCTURES

Mission: Analysis of the properties of cancer driver genes in different types of biological models
Vision: Our knowledge will expand the possibilities of targeted cancer therapy

Most types of cancer arise and develop due to genetic changes whose interactions lead to malignant stages. Tumors consist of subclones of cancer cells, and the mutations in the genomic DNA of these subclones can be very different. However, the genetic basis, i.e. the group of key mutations, was originally the same in all tumor cells. The main goal of the LCDB is to find out how specific genetic and associated molecular changes influence the properties of healthy and cancer cells. The LCDB focuses on analyzing the so-called cancer (driver) genes and investigates their functions. The long-term goal is to use the newly gained knowledge for the diagnosis or targeted therapy of selected malignant diseases.

It is important to emphasize that the LCDB has unique expertise in human disease modeling and in the use of sophisticated in vitro models such as organoids and induced pluripotent stem cells. Although the LCDB’s main priorities remain basic research, it is keen to capture and promote the translational potential of the results obtained. The LCDB sees its participation in the consortium as an excellent opportunity to significantly strengthen biomedical and preclinical research and to network organically with other oncology-oriented institutions in the Czech Republic.

SELECTED PUBLICATIONS

Berková L, Fazilaty H, Yang Q, Kubovčiak J, Stastna M, Hrckulak D, Vojtechova M, Dalessi T, Brügger MD, Hausmann G, Liberali P, Korinek V, Basler K, Valenta T. Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members. EMBO Rep. 2023 Sep 6;24(9):e56454. DOI: 10.15252/embr.202256454

Švec J, Šťastná M, Janečková L, Hrčkulák D, Vojtěchová M, Onhajzer J, Kříž V, Galušková K, Šloncová E, Kubovčiak J, Pfeiferová L, Hrudka J, Matěj R, Waldauf P, Havlůj L, Kolář M, Kořínek V. TROP2 Represents a Negative Prognostic Factor in Colorectal Adenocarcinoma and Its Expression Is Associated with Features of Epithelial-Mesenchymal Transition and Invasiveness. Cancers (Basel). 2022 Aug 26;14(17):4137. DOI: 10.3390/cancers14174137

Danek P, Kardosova M, Janeckova L, Karkoulia E, Vanickova K, Fabisik M, Lozano-Asencio C, Benoukraf T, Tirado-Magallanes R, Zhou Q, Burocziova M, Rahmatova S, Pytlik R, Brdicka T, Tenen DG, Korinek V, Alberich-Jorda M. β-Catenin-TCF/LEF signaling promotes steady-state and emergency granulopoiesis via G-CSF receptor upregulation. Blood. 2020 Nov 26;136(22):2574-2587. DOI: 10.1182/blood.2019004664

Tumova L, Pombinho AR, Vojtechova M, Stancikova J, Gradl D, Krausova M, Sloncova E, Horazna M, Kriz V, Machonova O, Jindrich J, Zdrahal Z, Bartunek P, Korinek V. Monensin inhibits canonical Wnt signaling in human colorectal cancer cells and suppresses tumor growth in multiple intestinal neoplasia mice. Mol Cancer Ther. 2014 Apr;13(4):812-22. DOI: 10.1158/1535-7163.MCT-13-0625
Fafilek B, Krausova M, Vojtechova M, Pospichalova V, Tumova L, Sloncova E, Huranova M, Stancikova J, Hlavata A, Svec J, Sedlacek R, Luksan O, Oliverius M, Voska L, Jirsa M, Paces J, Kolar M, Krivjanska M, Klimesova K, Tlaskalova-Hogenova H, Korinek V. Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells. Gastroenterology. 2013 Feb;144(2):381-391. DOI: 10.1053/j.gastro.2012.10.048