Virology and Molecular Carcinogenesis
Head: Vladimíra Koudeláková
Olomouc node
HOME INSTITUTION
Faculty of Medicine PU in Olomouc
RESEARCH PROGRAMME(S)
RP 3 - Biomarkers of cancers and cancer diagnostics
Unveiling the secrets of viruses to prevent the tumors of tomorrow.
- Mission: We conduct research on viral mechanisms of tumor development and develop strategies for their prevention to protect human health.
- Vision: Our vision is a world where knowledge about viruses enables the effective prevention of virus-associated cancers.
The research group focused on virology and molecular carcinogenesis is dedicated to gaining a deep understanding of the intricate relationship between viral infections and the development of cancer. The group studies the molecular mechanisms by which viruses, such as human papillomavirus (HPV), influence cellular processes and contribute to the malignant transformation of cells. One of the primary objectives of this research is to identify specific biomarkers that can be used for early cancer diagnosis and to assess the risk of cancer development in infected individuals.
SELECTED PUBLICATIONS
- Jaworek H, Koudelakova V, Oborna I, Zborilova B, Brezinova J, Ruzickova D, Vrbkova J, Kourilova P, Hajduch M. Impact of human papillomavirus infection on semen parameters and reproductive outcomes. Reprod Biol Endocrinol. 2021 Oct 9;19(1):156. DOI: 10.1186/s12958-021-00840-y
- Jaworek H, Koudelakova V, Drabek J, Vrbkova J, Zborilova B, Oborna I, Brezinova J, Marek R, Huml K, Vanek P, Hajduch M. A Head-to-Head Analytical Comparison of Cobas 4800 HPV, PapilloCheck HPV Screening, and LMNX Genotyping Kit HPV GP for Detection of Human Papillomavirus DNA in Cervical and Cervicovaginal Swabs. J Mol Diagn. 2018 Nov;20(6):849-858. DOI: 10.1016/j.jmoldx.2018.07.004
- Jaworek H, Koudelakova V, Slavkovsky R, Drabek J, Hajduch M. The absence of high-risk human papillomavirus in Czech non-small cell lung cancer cases. Biomed Pap. 2020 Mar;164(1):71-76. DOI: 10.5507/bp.2018.079
- Koudelakova V, Trojanec R, Vrbkova J, Donevska S, Bouchalova K, Kolar Z, Varanasi L, Hajduch M. Frequency of chromosome 17 polysomy in relation to CEP17 copy number in a large breast cancer cohort. Genes Chromosomes Cancer. 2016 May;55(5):409-17. DOI: 10.1002/gcc.22337
- Koudelakova V, Berkovcova J, Trojanec R, Vrbkova J, Radova L, Ehrmann J, Kolar Z, Melichar B, Hajduch M. Evaluation of HER2 Gene Status in Breast Cancer Samples with Indeterminate Fluorescence in Situ Hybridization by Quantitative Real-Time PCR. J Mol Diagn. 2015 Jul;17(4):446-55. DOI: 10.1016/j.jmoldx.2015.03.007
SPECIALIZED EXPERTISE AND TECHNOLOGY
Genetic profiling and cancer diagnostics
Next-genome sequencing
Development of non-invasive sampling for tumor diagnostics
COLLABORATION WITH LARGE RESEARCH INFRASTRUCTURES AND RESEARCH CENTRES
National infrastructure for translational medicine EATRIS-CZ