Virology and Molecular Carcinogenesis
Head: Vladimíra Koudeláková
Olomouc node
HOME INSTITUTION
Faculty of Medicine PU in Olomouc
RESEARCH PROGRAMME(S)
RP 3 - Biomarkers of cancers and cancer diagnostics
The research is focused on human virology, public health surveillance, the molecular mechanisms of virus-driven infections, diseases, and, specifically, carcinogenesis. The group is focused mainly on HPV-associated diseases, SARS-CoV-2 immunity, and cancer genetics. The researchers from the group focus on virology and molecular carcinogenesis and are involved in the molecular investigation of human papillomaviruses (HPV) and, recently, in SARS-CoV-2 infections. The workplace is fully equipped with state-of-the-art instruments for genetic and molecular biology analyses of human biological materials.
Research objectives
- Human virology.
- Public health surveillance.
- Molecular carcinogenesis of HPV-driven cancers.
- National screening and vaccination programs improvement.
- New approaches in screening testing.
SELECTED PUBLICATIONS
- Jaworek H, Koudelakova V, Oborna I, Zborilova B, Brezinova J, Ruzickova D, Vrbkova J, Kourilova P, Hajduch M. Impact of human papillomavirus infection on semen parameters and reproductive outcomes. Reprod Biol Endocrinol. 2021 Oct 9;19(1):156. DOI: 10.1186/s12958-021-00840-y
- Jaworek H, Koudelakova V, Drabek J, Vrbkova J, Zborilova B, Oborna I, Brezinova J, Marek R, Huml K, Vanek P, Hajduch M. A Head-to-Head Analytical Comparison of Cobas 4800 HPV, PapilloCheck HPV Screening, and LMNX Genotyping Kit HPV GP for Detection of Human Papillomavirus DNA in Cervical and Cervicovaginal Swabs. J Mol Diagn. 2018 Nov;20(6):849-858. DOI: 10.1016/j.jmoldx.2018.07.004
- Jaworek H, Koudelakova V, Slavkovsky R, Drabek J, Hajduch M. The absence of high-risk human papillomavirus in Czech non-small cell lung cancer cases. Biomed Pap. 2020 Mar;164(1):71-76. DOI: 10.5507/bp.2018.079
- Koudelakova V, Trojanec R, Vrbkova J, Donevska S, Bouchalova K, Kolar Z, Varanasi L, Hajduch M. Frequency of chromosome 17 polysomy in relation to CEP17 copy number in a large breast cancer cohort. Genes Chromosomes Cancer. 2016 May;55(5):409-17. DOI: 10.1002/gcc.22337
- Koudelakova V, Berkovcova J, Trojanec R, Vrbkova J, Radova L, Ehrmann J, Kolar Z, Melichar B, Hajduch M. Evaluation of HER2 Gene Status in Breast Cancer Samples with Indeterminate Fluorescence in Situ Hybridization by Quantitative Real-Time PCR. J Mol Diagn. 2015 Jul;17(4):446-55. DOI: 10.1016/j.jmoldx.2015.03.007