Laboratory of Cancer Treatment and Tissue Regeneration
Head: Václav Liška
Prague node
HOME INSTITUTION
Faculty of Medicine in Pilsen
RESEARCH PROGRAMME(S)
RP 3 - Biomarkers of cancers and cancer diagnostics
Good research tells us why cancer occurs and how it behaves. The best research tells us how to prevent and treat it.
- Mission: To understand the behaviour of gastrointestinal cancers in relation to diagnostic and therapeutic strategies.
- Vision: To increase the clinical potential of therapeutic strategies, improve quality of life and overall survival of our patients by studying cancer and regeneration of affected tissues in clinically relevant in vitro and in vivo models.
Our laboratory deals mainly with the clinical side of cancer research. We represent a wide team, connecting clinicians – especially from surgical disciplines, oncologists, and radiologists – with academic researchers not only from the Biomedical Center but also from other institutions, such as the Academy of Sciences of the Czech Republic. We deal with long-term research issues, especially colorectal cancer, liver metastases, pancreatic cancer, and other gastrointestinal malignancies. Our group has created an extensive database of prospectively monitored diseases and their clinical development in connection with treatment. Concerning their processing, we are mainly involved in the formulation of clinical issues related to the diagnosis, treatment, and prediction of disease outcomes.
SELECTED PUBLICATIONS
- Anthis AHC, Kilchenmann S, Murdeu M, LeValley PJ, Wolf M, Meyer C, Cipolato O, Tibbitt MW, Rosendorf J, Liska V, Rduch T, Herrmann IK. Reversible Mechanical Contraception and Endometriosis Treatment Using Stimuli-Responsive Hydrogels. Adv Materials. 2024 Feb 1:e2310301. DOI: 10.1002/adma.202310301
- Pardini B, Ferrero G, Tarallo S, Gallo G, Francavilla A, Licheri N, Trompetto M, Clerico G, Senore C, Peyre S, Vymetalkova V, Vodickova L, Liska V, Vycital O, Levy M, Macinga P, Hucl T, Budinska E, Vodicka P, Cordero F, Naccarati A. A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study. Gastroenterology. 2023 Sep;165(3):582-599.e8. DOI: 10.1053/j.gastro.2023.05.037
- Anthis A, Abundo MP, Neuer A, Tsolaki E, Rosendorf J, Rduch T, Starsich F, Weisse B, Liška V, Schlegel A, Shapiro M, Herrmann I. Modular stimuli-responsive hydrogel sealants for early gastrointestinal leak detection and containment. Nat Commun. 2022 Nov 27;13(1):7311. DOI: 10.1038/s41467-022-34272-y
- Kunzmann AT, Proenca MA, Jordao HW, Jirásková K, Schneiderová M, Levý M, Liška V, Büchler T, Vodičková L, Vymetálková V, Silva AE, Vodička P, Hughes DJ. Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients. Eur J Clin Microbiol Infect Dis. 2019 Oct;38(10):1891-1899. DOI: 10.1007/s10096-019-03649-1
- Svoboda M, Slyšková J, Schneiderová M, Makovický P, Bielik L, Levý M, Lipská L, Hemmelová B, Kala Z, Protivanková M, Vyčítal O, Liška V, Schwarzová L, Vodičková L, Vodička P. HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. Carcinogenesis. 2014 Jul;35(7):1510-5. DOI: 10.1093/carcin/bgu055
COLLABORATION WITHIN THE NICR
Kari Hemminki
(Prague node, Faculty of Medicine in Pilsen)
Ludmila Vodičková
(Prague node, Institute of Experimental Medicine of the Czech Academy of Sciences)
Pavel Souček
(Prague node, Faculty of Medicine in Pilsen)
Pavel Vodička
(Prague node, Institute of Experimental Medicine of the Czech Academy of Sciences)
SPECIALIZED EXPERTISE AND TECHNOLOGY
Clinically relevant in vitro and in vivo models of cancer and regeneration of affected tissues
Porcine primary cell isolation and culture (hepatocytes, mesenchymal stem cells, endothelial cells)
Development and customization of organ / tissue decellularization procedures
Design and testing of tissue culture bioreactors
Biostatistics, advanced data visualization