Václav Ranc

Nanomaterials in Medicine

Head: Václav Ranc
Olomouc node

vaclav.ranc@upol.cz
website of the Institute

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Faculty of Medicine PU in Olomouc

RESEARCH PROGRAMME(S)

RP 2 - Research and development of anticancer pharmaceuticals and therapeutic methods
RP 3 - Biomarkers of cancers and cancer diagnostics

Nanomedicine – Delivering the future of targeted therapy and diagnostics.

FOCUS OF RESEARCH
SELECTED PUBLICATIONS
EXPERTISE AND TECHNOLOGY
COLLABORATION WITHIN THE NICR
COLLABORATION WITH INFRASTRUCTURES
  • Mission: To develop methods for targeted drug delivery based on hybrid nanomaterials.
  • Vision: To develop a nanoplatform that will increase the effectiveness of cancer treatment and reduce the side effects of current treatments.

Nanomedicine, particularly the use of nanoplatforms for drug delivery, is a rapidly evolving field with immense potential. These platforms, constructed from nanoscale 2D or 3D materials, hold promise for both disease diagnosis and targeted drug therapy.

Nanotechnology offers significant advantages over traditional approaches. In cancer treatment, for example, it allows for the site-specific delivery of highly effective drugs, minimizing side effects. Additionally, the unique optical and electronic properties of many nanomaterials open doors for novel diagnostic techniques.

While numerous nanomaterials for drug delivery and biomarker sensing have been explored in recent years, their widespread clinical application remains limited. A key challenge lies in translating fundamental research into practical medical solutions.

Building on our expertise in developing sensors for magnetically assisted Raman spectroscopy and drug delivery systems using 2D nanomaterials, our research group focuses on creating 2D and 3D nanoplatforms for targeted drug delivery in cancers like breast cancer, gliomas, and osteosarcoma.

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SELECTED PUBLICATIONS
  • Balzerova A, Fargasova A, Markova Z, Ranc V, Zboril R. Magnetically-assisted surface enhanced raman spectroscopy (MA-SERS) for label-free determination of human immunoglobulin G (IgG) in blood using Fe3O4@Ag nanocomposite. Anal Chem. 2014 Nov 18;86(22):11107-14. DOI: 10.1021/ac503347h
  • Balzerová A, Opletalová A, Ranc V, Radek Zbořil. Multiplex competitive analysis of HER2 and EpCAM cancer markers in whole human blood using Fe2O3@Ag nanocomposite. Applied Materials Today. 2018;13:166-173. DOI: 10.1016/j.apmt.2018.08.016
  • Chaloupková Z, Balzerová A, Bařinková J, Medříková Z, Šácha P, Beneš P, Ranc V, Konvalinka J, Zbořil R. Label-free determination of prostate specific membrane antigen in human whole blood at nanomolar levels by magnetically assisted surface enhanced Raman spectroscopy. Anal Chim Acta. 2018 Jan 2;997:44-51. DOI: 10.1016/j.aca.2017.10.008
  • Giusto E, Žárská L, Beirne DF, Rossi A, Bassi G, Ruffini A, Montesi M, Montagner D, Ranc V, Panseri S. Graphene Oxide Nanoplatforms to Enhance Cisplatin-Based Drug Delivery in Anticancer Therapy. Nanomaterials (Basel). 2022 Jul 11;12(14):2372. DOI: 10.3390/nano12142372
COLLABORATION WITHIN THE NICR

Jan Bouchal
(Olomouc node, Faculty of Medicine PU in Olomouc)

Milan Urban
(Olomouc node, Faculty of Medicine PU in Olomouc)

SPECIALIZED EXPERTISE AND TECHNOLOGY

Development of plasmonic nanomaterials

Development of 2D (magnetic) delivery systems

Raman spectroscopy imaging

Infrared spectroscopy

COLLABORATION WITH LARGE RESEARCH INFRASTRUCTURES AND RESEARCH CENTRES

National infrastructure for biological and biomedical imaging Czech-Bioimaging