Aleksi Šedo

Laboratory of cancer cell biology (LCCB)

Head: Aleksi Šedo
Prague node

aleksi@cesnet.cz
website of the Institute
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HOME INSTITUTION

First Faculty of Medicine CU

RESEARCH PROGRAMME(S)

RP 1 - Molecular basis of cancer and molecular targets

Watch out, dude! A tumor is not just cancer cells!

COLLABORATION WITH INFRASTRUCTURES

Mission: To search for pathogenetically relevant processes that drive brain tumour progression
Vision: To identify and target therapeutically or diagnostically relevant cellular and molecular targets in primary and secondary brain tumors

LCCB focuses on the role of plasma membrane-bound proteases in various physiological and pathophysiological processes, particularly in the pathogenesis of cancer. In addition to focused research on intercellular interactions in the tumor microenvironment that drive tumor growth, neoangiogenesis, and dysregulation of the anti-tumor local and systemic immune response, our translational projects focus on the development of innovative diagnostic (imaging) and therapeutic concepts exploiting different molecular targets, particularly in glioblastomas and brain metastases.

In collaboration with other groups in the consortium, we are developing and testing novel compounds to influence the behaviour of cell populations present in the tumour microenvironment and to use identified molecular targets for diagnostic or therapeutic applications.

SELECTED PUBLICATIONS

Vymola P, Garcia-Borja E, Cervenka J, Balaziova E, Vymolova B, Veprkova J, Vodicka P, Skalnikova H, Tomas R, Netuka D, Busek P, Sedo A. : Fibrillar extracellular matrix produced by pericyte-like cells facilitates glioma cell dissemination. Brain Pathol. 2024 May 5:e13265. DOI: 10.1111/bpa.13265
Konečná D, Výmola P, Ternerová N, Výmolová B, Garcia-Borja E, Mateu R, Šroubek F, Pankrác J, Widen JC, Bogyo M, Netuka D, Bušek P, Šedo A.: Molecularly targeted protease-activated probes for visualization of glioblastoma: a comparison with 5-ALA. J Neurosurg. 2024 Mar 29:1-12. DOI: 10.3171/2024.1.JNS231137
Zubaľ M, Výmolová B, Matrasová I, Výmola P, Vepřková J, Syrůček M, Tomáš R, Vaníčková Z, Křepela E, Konečná D, Bušek P, Šedo A.: Fibroblast activation protein as a potential theranostic target in brain metastases of diverse solid tumours. Pathology. 2023 Jun 16:S0031-3025(23)00137-X. DOI: 10.1016/j.pathol.2023.05.003
Dvořáková P, Bušek P, Knedlík T, Schimer J, Etrych T, Kostka L, Stollinová Šromová L, Šubr V, Šácha P, Šedo A, Konvalinka J: Inhibitor-Decorated Polymer Conjugates Targeting Fibroblast Activation Protein. J Med Chem. 2017 Oct 26;60(20):8385-8393. DOI: 10.1021/acs.jmedchem.7b00767
Sedo A. and Mentlein R (eds.). Glioma Cell Biology. Book. Springer, 2014. ISBN 978-3-7091-1430-8