Pavel Souček

We are involved in comprehensive research on the influence of molecular factors on tumor development and progression. One of our goals is to use tumor growth characteristics for defining therapeutically significant profiles and ultimately contribute to better targeting of available oncology treatments. We monitor the mechanisms of action of known antitumor drugs on model cell lines and look for ways to increase their therapeutic effect. We are also studying new drugs that have not yet been included in clinical trials, and the development of animal models of tumor growth, e.g. patient xenografts, is ongoing. Our main goal is to contribute to the progress of precision oncology.

Research objectives:

1. We plan to integrate a multi-omic tumor profile and find out what role the genome plays directly, and then discern the additional contribution of the epigenome (methylome and miRNOMe, possibly other non-coding RNA types) in the context of the tumor cell phenotype (transcriptome and proteome, possibly metabolome).
2. We aim to define the molecular profile of both tumor cells and tumors as a bulk and ultimately provide biomarkers with prognostic and predictive value for the overall oncological treatment of the patient, including a personalized approach. We will pay specific attention to signs of resistance to oncological treatment and its development during the transition from primary to metastatic disease.