Pediatric Oncology Task force
Head: Jaroslav Štěrba
Brno node
HOME INSTITUTION
Faculty of Medicine MU
RESEARCH PROGRAMME(S)
RP 1 - Molecular basis of cancer and molecular targets
RP 2 - Research and development of anticancer pharmaceuticals and therapeutic methods
Pediatric tumors are highly complex and very dynamic.
- Mission: Personalized/precision pediatric oncology.
- Vision: Incorporation of biomarker based precision/personalized pediatric oncology into standard of care.
Cancer is a disease of the genome. Medical genomics and epigenomics have significantly changed the way we understand these diseases today. It expands our knowledge of tumor biology and allows us to identify new therapeutic targets. At the same time, today it helps directly in clinical practice by enabling individually formulated antitumor treatment reflecting both the uniqueness of the tumor itself and of each of its hosts. Harnessing the power of genomics in oncology care has also significantly improved treatment outcomes for oncology patients. As part of our research, we focus on the search for genomic changes in solid tumors, especially in high-risk refractory childhood tumors, and on evaluating their significance for more accurate diagnosis and individualized treatment.
SELECTED PUBLICATIONS
- Strublová, L., Kepák, T., Kuruczová, D., Zlámal, F., Holíková, M., Kepáková, K., Sterba, J., Bienertová-Vasku, J., Socioeconomic status and adiposity in childhood cancer survivors: A cross-sectional retrospective study, PLOS ONE, 2024, Volume 19, Issue 2, DOI: 10.1371/journal.pone.0298068
- Palova, H., Das, A., Pokorna, P., Bajciova, V., Pavelka, Z., Jezova, M., Pal, K., Dimayacyac JR., Negm, L., Stengs, L., Bianchi, V., Vejmelkova, K., Noskova, K., Jarosova, M., Mejstrikova, S., Mudry, P., Kyr, M., Merta, T., Tinka, P., Drabova, K., Aulicka, S., Jugas, R., Tabori, U., Slaby, O., Sterba, J., Precision immuno-oncology approach for four malignant tumors in siblings with constitutional mismatch repair deficiency syndrome, NPJ, Precision onkology 2024, 8:110, DOI: 10.1038/s41698-024-00597-8
- Stourac, J., Borko, S., Khan, RT., Pokorna, P., Dobias, A., Planas-Iglesias, J., Mazurenko, S., Pinto, G., Szotkowska, V., Sterba, J. PredictONCO: a web tool supporting decision-making in precision oncology by extending the bioinformatics predictions with advanced computing and machine learning, Briefings in Bioinformatics, 2024, Volume 25, Issue 1, DOI: 10.1093/bib/bbad441
- G.Bisogno, V. Minard-Colin, I. Zanetti, A. Ferrari, et.al., Nonmetastatic Rhabdomyosarcoma in Children and Adolescents: Overall Results of the European Pediatric Soft Tissue Sarcoma Study Group RMS2005 Study, Journal of Clinical Oncology, 2023, Vol. 41, Issue 13 DOI: 10.1200/JCO.22.0209
- Sterba, P. Pokorna, R. Faberova, B. Pinkova, J. Skotakova, A. Seehofnerova, J. Blatny, L. Janigova, O. Koskova, H. Palova, M. Mahdal, L. Pazourek, P. Jabandziev, O. Slabý, P. Mudry, J. Sterba, Targeted treatment of severe vascular malformations harboring PIK3CA and TEK mutations with alpelisib is highly effective with limited toxicity, , Scientific Reports, 2023, 13:10499, Vol. 13, Issue 1, DOI: 10.1038/s41598-023-37468-4
- Elitzur S, Vora A, Burkhardt B, Inaba H, Attarbaschi A, Baruchel A, Escherich G, Gibson BE, Liu HC, Loh ML, Moorman AV, Möricke A, Pieters R, Uyttebroeck A, Baird S, Bartram J, Barzilai-Birenboim S, Batra S, Ben-Harosh M, Bertrand Y, Buitenkamp T, Caldwell K, Drut R, Geerlinks AV, Gilad G, Grainger J, Haouy S, Heaney NB, Huang M, Ingham D, Krenova Z, Kuhlen M,Lehrnbecher T, Manabe A, Niggli F, Paris C, Revel-Vilk S, Rohrlich P, Sinno MG, Szczepanski T, Tamesberger M, Warrier R, Wolfl M, Nirel R, Izraeli S, Borkhardt A, Schmiegelow K., EBV-driven lymphoid neoplasms associated with pediatric ALL maintenance therapy. Blood 2022, Volume 141, Issue 7, Page 743-755, DOI: 10.1182/blood.2022016975
COLLABORATION WITHIN THE NICR
Ondřej Slabý
(Brno node, Faculty of Medicine MU/CEITEC MU)
Renata Veselská
(Brno node, Faculty of Science MU)
Šárka Pospíšilová
(Brno node, Faculty of Medicine MU/CEITEC MU)
SPECIALIZED EXPERTISE AND TECHNOLOGY
Precision oncology, metronomics
Immunotherapy in pediatric oncology
Late effects, epidemiology of childhood cancer
Comprehensive molecular profiling