Childhood Leukaemia Investigation Prague
Head: Jan Trka
Prague node
HOME INSTITUTION
Second Faculty of Medicine CU
RESEARCH PROGRAMME(S)
RP 1 - Molecular basis of cancer and molecular targets
Survive in the Czech science support system!
- Mission: Molecular diagnosis for every child with cancer.
- Vision: Optimal treatment for every child with cancer.
CLIP is the only research and diagnostic centre in the Czech Republic primarily focused on childhood cancer and leukaemia. It is one of the research centres of European standard, with continuous publication activity in leading journals in the field.
SELECTED PUBLICATIONS
- Zaliova M, Zuna J, Winkowska L, Janotova I, Skorepova J, Lukes J, Meyer C, Marschalek R, Novak Z, Domansky J, Stary J, Sramkova L, Trka J. Genomic DNA-based measurable residual disease monitoring in pediatric acute myeloid leukemia: unselected consecutive cohort study. Leukemia. 2024 Jan;38(1):21-30. DOI: 10.1038/s41375-023-02083-9
- Svaton M, Skotnicova A, Reznickova L, Rennerova A, Valova T, Kotrova M, van der Velden VHJ, Brüggemann M, Darzentas N, Langerak AW, Zuna J, Stary J, Trka J, Fronkova E. NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on an MRD-based protocol. Blood. 2023 Feb 2;141(5):529-533. DOI: 10.1182/blood.2022017003
- Zuna J, Hovorkova L, Krotka J, Koehrmann A, Bardini M, Winkowska L, Fronkova E, Alten J, Koehler R, Eckert C, Brizzolara L, Trkova M, Stuchly J, Zimmermann M, De Lorenzo P, Valsecchi MG, Conter V, Stary J, Schrappe M, Biondi A, Trka J, Zaliova M, Cazzaniga G, Cario G. Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease. Leukemia. 2022 Dec;36(12):2793-2801. DOI: 10.1038/s41375-022-01668-0
- Misove A, Vicha A, Broz P, Vanova K, Sumerauer D, Stolova L, Sramkova L, Koblizek M, Zamecnik J, Kyncl M, Holubova Z, Liby P, Taborsky J, Benes V 3rd, Pernikova I, Jones DTW, Sill M, Stancokova T, Krskova L, Zapotocky M. Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas. Acta Neuropathol Commun. 2022 Sep 26;10(1):143. DOI: 10.1186/s40478-022-01446-0
- Zaliova M, Stuchly J, Winkowska L, Musilova A, Fiser K, Slamova M, Starkova J, Vaskova M, Hrusak O, Sramkova L, Stary J, Zuna J, Trka J. Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort. Haematologica. 2019 Jul;104(7):1396-1406. DOI: 10.3324/haematol.2018.204974
- Hrusak O, de Haas V, Stancikova J, Vakrmanova B, Janotova I, Mejstrikova E, Capek V, Trka J, Zaliova M, Luks A, Bleckmann K, Möricke A, Irving J, Konatkowska B, Alexander TB, Inaba H, Schmiegelow K, Stokley S, Zemanova Z, Moorman AV, Rossi JG, Felice MS, Dalla-Pozza L, Morales J, Dworzak M, Buldini B, Basso G, Campbell M, Cabrera ME, Marinov N, Elitzur S, Izraeli S, Luria D, Feuerstein T, Kolenova A, Svec P, Kreminska O, Rabin KR, Polychronopoulou S, da Costa E, Marquart HV, Kattamis A, Ratei R, Reinhardt D, Choi JK, Schrappe M, Stary J. International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia. Blood. 2018 Jul 19;132(3):264-276. DOI: 10.1182/blood-2017-12-821363
COLLABORATION WITHIN THE NICR
Tomáš Etrych
(Prague node, Institute of Macromolecular Chemistry of the Czech Academy of Sciences)
Vítězslav Bryja
(Brno node, Faculty of Science MU)
SPECIALIZED EXPERTISE AND TECHNOLOGY
Flow cytometry
Mass cytometry
Molecular genetics
Bulk and single-cell genomics
Metabolomics
COLLABORATION WITH LARGE RESEARCH INFRASTRUCTURES AND RESEARCH CENTRES
European Scientific foundation for Laboratory Hemato Oncology ESLHO