Molecular biology of cancer: Biomarkers of prognosis of solid malignancies and biomarkers of terapeutic interventions
Head: Pavel Vodička
Prague node
HOME INSTITUTION
Institute of Experimental Medicine of the Czech Academy of Sciences
RESEARCH PROGRAMME(S)
RP 3 - Biomarkers of cancers and cancer diagnostics
Tumor is diverse, multifaceted adversary, but same time our fatal associate.
- Mission: To elucidate processes of tumor progression and identify biomarkers of individual therapeutic response of patients.
- Vision: To understand tumor progression along with mapping of prognosis and prediction in oncological patients with the aim to make therapy more tailored and effective.
We will identify molecular parameters of genetic modification, such as DNA damage, changes in the regulation of gene expressions, including epigenetic factors (miRNA expression, DNA methylation). All these parameters describing genomic instability will be followed in tumors of gastrointestinal tracts and ovary. We will map progression from primary tumors to synchronous and/or metachronous metastatic disease with the aim to estimate the prognosis of patient. In this context we will focus on unfolding of chemoresistance, which is principal cause of death on malignant diseases.
SELECTED PUBLICATIONS
- Vodickova L, Horak J, Vodicka P. Genetic Susceptibility in Understanding of Pancreatic Ductal Adenocarcinoma Risk: A Decade-Long Effort of the PANDORA Consortium. Cancer Epidemiol Biomarkers Prev. 2022 May 4;31(5):942-948. DOI: 10.1158/1055-9965.EPI-21-1340
- Cervena K, Novosadova V, Pardini B, Naccarati A, Opattova A, Horak J, Vodenkova S, Buchler T, Skrobanek P, Levy M, Vodicka P, Vymetalkova V. Analysis of MicroRNA Expression Changes During the Course of Therapy In Rectal Cancer Patients. Front Oncol. 2021 Sep 2;11:702258. DOI: 10.3389/fonc.2021.702258
- Pistoni L, Gentiluomo M, Lu Y, López de Maturana E, Hlavac V, Vanella G, Darvasi E, Milanetto AC, Oliverius M, Vashist Y, Di Leo M, Mohelnikova-Duchonova B, Talar-Wojnarowska R, Gheorghe C, Petrone MC, Strobel O, Arcidiacono PG, Vodickova L, Szentesi A, Capurso G, Gajdán L, Malleo G, Theodoropoulos GE, Basso D, Soucek P, Brenner H, Lawlor RT, Morelli L, Ivanauskas A; PanGenEU Study Investigators, Kauffmann EF, Macauda A, Gazouli M, Archibugi L, Nentwich M, Loveček M, Cavestro GM, Vodicka P, Landi S, Tavano F, Sperti C, Hackert T, Kupcinskas J, Pezzilli R, Andriulli A, Pollina L, Kreivenaite E, Gioffreda D, Jamroziak K, Hegyi P, Izbicki JR, Testoni SGG, Zuppardo RA, Bozzato D, Neoptolemos JP, Malats N, Canzian F, Campa D. Associations between pancreatic expression quantitative traits and risk of pancreatic ductal adenocarcinoma. Carcinogenesis. 2021 Aug 19;42(8):1037-1045. DOI: 10.1093/carcin/bgab057
- Corlin L, Ruan M, Tsilidis KK, Bouras E, Yu YH, Stolzenberg-Solomon R, Klein AP, Risch HA, Amos CI, Sakoda LC, Vodička P, Rish PK, Beck J, Platz EA, Michaud DS. Two-Sample Mendelian Randomization Analysis of Associations Between Periodontal Disease and Risk of Cancer. JNCI Cancer Spectr. 2021 Apr 19;5(3):pkab037. DOI: 10.1093/jncics/pkab037
- Galeotti AA, Gentiluomo M, Rizzato C, Obazee O, Neoptolemos JP, Pasquali C, Nentwich M, Cavestro GM, Pezzilli R, Greenhalf W, Holleczek B, Schroeder C, Schöttker B, Ivanauskas A, Ginocchi L, Key TJ, Hegyi P, Archibugi L, Darvasi E, Basso D, Sperti C, Bijlsma MF, Palmieri O, Hlavac V, Talar-Wojnarowska R, Mohelnikova-Duchonova B, Hackert T, Vashist Y, Strouhal O, van Laarhoven H, Tavano F, Lovecek M, Dervenis C, Izbéki F, Padoan A, Małecka-Panas E, Maiello E, Vanella G, Capurso G, Izbicki JR, Theodoropoulos GE, Jamroziak K, Katzke V, Kaaks R, Mambrini A, Papanikolaou IS, Szmola R, Szentesi A, Kupcinskas J, Bursi S, Costello E, Boggi U, Milanetto AC, Landi S, Gazouli M, Vodickova L, Soucek P, Gioffreda D, Gemignani F, Brenner H, Strobel O, Büchler M, Vodicka P, Paiella S, Canzian F, Campa D. Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction. J Med Genet. 2021 Jun;58(6):369-377. DOI: 10.1136/jmedgenet-2020-106961
COLLABORATION WITHIN THE NICR
Ludmila Vodičková
(Prague node, Institute of Experimental Medicine of the Czech Academy of Sciences)
Pavel Rössner
(Prague node, Institute of Experimental Medicine of the Czech Academy of Sciences)
SPECIALIZED EXPERTISE AND TECHNOLOGY
Digital PCR
Fluorescent microscop
Western blott
RT PCR
NGS technologies
COLLABORATION WITH LARGE RESEARCH INFRASTRUCTURES AND RESEARCH CENTRES
National infrastructure for translational medicine EATRIS-CZ