Molecular biology of cancer: Risk factors and biomarkers of an onset of malignant diseases
Head: Ludmila Vodičková
Prague node
HOME INSTITUTION
Institute of Experimental Medicine of the Czech Academy of Sciences
RESEARCH PROGRAMME(S)
RP 3 - Biomarkers of cancers and cancer diagnostics
The tumor cell never gives up!
- Mission: To make tumor visible by the means of biomarkers and dissect the treatable targets.
- Vision: To map risk factors in malignant diseases and identify molecular biomarkers of onset and progressioin of gastrointestinal and some gynaecological tumours.
We will investigate modification of genetic information, mainly DNA damage, changes in gene expression, including epigenetic markers in tumors of gastrointestinal tract and some gynaecological tumors. Systematic approach will be applied in the study of heritability and individual susceptibility predominantly in colorectal cancer and pancreatic ductal adenocarcinoma. In addition, we will focus (with other subgroups of IEM) on gene-gene and gene – environmental interactions
SELECTED PUBLICATIONS
- Jungwirth J, Urbanova M, Boot A, Hosek P, Bendova P, Siskova A, Svec J, Kment M, Tumova D, Summerova S, Benes Z, Buchler T, Kohout P, Hucl T, Matej R, Vodickova L, van Wezel T, Vodicka P, Vymetalkova V. Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition. Sci Rep. 2022 Feb 16;12(1):2570. DOI: 10.1038/s41598-022-06498-9
- Vodicka P, Andera L, Opattova A, Vodickova L. The Interactions of DNA Repair, Telomere Homeostasis, and p53 Mutational Status in Solid Cancers: Risk, Prognosis, and Prediction. Cancers (Basel). 2021 Jan 27;13(3):479. DOI: 10.3390/cancers13030479
- Bendova P, Pardini B, Susova S, Rosendorf J, Levy M, Skrobanek P, Buchler T, Kral J, Liska V, Vodickova L, Landi S, Soucek P, Naccarati A, Vodicka P, Vymetalkova V. Genetic variations in microRNA-binding sites of solute carrier transporter genes as predictors of clinical outcome in colorectal cancer. Carcinogenesis. 2021 Apr 17;42(3):378-394. DOI: 10.1093/carcin/bgaa136
- Vodicka P, Polivkova Z, Sytarova S, Demova H, Kucerova M, Vodickova L, Polakova V, Naccarati A, Smerhovsky Z, Ambrus M, Cerna M, Hemminki K. Chromosomal damage in peripheral blood lymphocytes of newly diagnosed cancer patients and healthy controls. Carcinogenesis. 2010 Jul;31(7):1238-41. DOI: 10.1093/carcin/bgq056
- Tsilidis KK, Papadimitriou N, Dimou N, Gill D, Lewis SJ, Martin RM, Murphy N, Markozannes G, Zuber V, Cross AJ, Burrows K, Lopez DS, Key TJ, Travis RC, Perez-Cornago A, Hunter DJ, van Duijnhoven FJB, Albanes D, Arndt V, Berndt SI, Bézieau S, Bishop DT, Boehm J, Brenner H, Burnett-Hartman A, Campbell PT, Casey G, Castellví-Bel S, Chan AT, Chang-Claude J, de la Chapelle A, Figueiredo JC, Gallinger SJ, Giles GG, Goodman PJ, Gsur A, Hampe J, Hampel H, Hoffmeister M, Jenkins MA, Keku TO, Kweon SS, Larsson SC, Le Marchand L, Li CI, Li L, Lindblom A, Martín V, Milne RL, Moreno V, Nan H, Nassir R, Newcomb PA, Offit K, Pharoah PDP, Platz EA, Potter JD, Qi L, Rennert G, Sakoda LC, Schafmayer C, Slattery ML, Snetselaar L, Schenk J, Thibodeau SN, Ulrich CM, Van Guelpen B, Harlid S, Visvanathan K, Vodickova L, Wang H, White E, Wolk A, Woods MO, Wu AH, Zheng W, Bueno-de-Mesquita B, Boutron-Ruault MC, Hughes DJ, Jakszyn P, Kühn T, Palli D, Riboli E, Giovannucci EL, Banbury BL, Gruber SB, Peters U, Gunter MJ. Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study. Am J Clin Nutr. 2021 Jun 1;113(6):1490-1502. DOI: 10.1093/ajcn/nqab003
COLLABORATION WITHIN THE NICR
Jiří Neužil
(Prague node, Institute of Biotechnology of the Czech Academy of Sciences)
Kari Hemminki
(Prague node, Faculty of Medicine in Pilsen)
Ondřej Slabý
(Brno node, Faculty of Medicine MU/CEITEC MU)
Pavel Rössner
(Prague node, Institute of Experimental Medicine of the Czech Academy of Sciences)
Pavel Souček
(Prague node, Faculty of Medicine in Pilsen)
Pavel Vodička
(Prague node, Institute of Experimental Medicine of the Czech Academy of Sciences)
Václav Liška
(Prague node, Faculty of Medicine in Pilsen)
Zdeněk Kleibl
(Prague node, First Faculty of Medicine CU)
SPECIALIZED EXPERTISE AND TECHNOLOGY
Digital PCR
Fluorescent microscop
COLLABORATION WITH LARGE RESEARCH INFRASTRUCTURES AND RESEARCH CENTRES
National infrastructure for translational medicine EATRIS-CZ