Výzkumné instituce sdružené v NÚVR se mj. zavázaly k tomu, že vytvoří více než 600 klasifikovatelných výstupů, z toho přes 400 odborných publikací. Zde najdete přehled prací zveřejněných v odborných časopisech spadajících do prvního kvartilu daného oboru a některé další výstupy projektu.

Integrative NGS testing reveals clonal dynamics of adverse genomic defects contributing to a natural progression in treatment-naïve CLL patients. Veronika Navrkalová, Karla Plevová, Lenka Radová, Jakub Paweł Porc, Karol Pál, Jitka Malčíková, Šárka Pavlová, Michael Doubek, Anna Panovská, Jana Kotašková a Šárka Pospíšilová. British journal of haematology. Hoboken: Wiley-Blackwell, 2024, roč. 204, č. 1, s. 240-249. 

doi: 10.1111/bjh.19191. PMID: 38062779

 

De novo accelerated phase of chronic myeloid leukemia should be recognized even in the era of tyrosine kinase inhibitors. Tomáš Horňák, Jiří Mayer, Petra Čičátková, Lukáš Semerád, Anežka Kvetková, Hana Klamova, Edgar Faber, Petra Belohlavkova, Michal Karas, Lukas Stejskal, Eduard Cmunt, Olga Cerna, Dana Srbova, Hana Zizkova, Lucia Vrablova, Ivana Skoumalova, Jaroslava Voglova, Tereza Jurkova, Marika Chrpava, Tomáš Jurček, Ivana Ježíšková, Marie Jarošová, Katerina Machova Polakova, Tomas Papajik, Pavel Zak, Pavel Jindra a Daniela Žáčková. American Journal of Hematology. Hoboken: Wiley-Blackwell, 2024, 4 s. 

doi: 10.1002/ajh.27229. PMID: 38317312

 

Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer. Anna Vyhlídalová Kotrbová, Kristína Gömöryová, Antónia Mikulová, Hana Plešingerová, Stanislava Sladeček, Marek Kravec, Šárka Hrachovinová, David Potěšil, Garett Dunsmore, Camille Bleriot, Mathilde Bied, Jan Kotouček, Markéta Bednaříková, Jitka Hausnerová, Luboš Minář, Igor Crha, Michal Felsinger, Zbyněk Zdráhal, Florent Ginhoux, Vít Weinberger, Vítězslav Bryja a Vendula Hlaváčková Pospíchalová. Journal of Extracellular Vesicles. Wiley, 2024, roč. 13, č. 3, s. 1-22. 

doi: 10.1002/jev2.12420. PMID: 38490958

 

Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells. Elena Garcia-Borja, František Siegl, Rosana Mateu, Ondřej Slabý, Aleksi Šedo, Petr Bušek a Jiří Šána. Biomarker Research. London: BMC, 2024, roč. 12, č. 1, s. 1-24.

doi: 10.1186/s40364-024-00563-3. PMID: 38303021

 

STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma. Nicole Prutsch, Shuning He, Alla Berezovskaya, Adam D Durbin, Neekesh V Dharia, Kelsey A Maher, Jamie D Matthews, Lucy Hare, Suzanne Dawn Turner, Kimberly Stegmaier, Lukas Kenner, Olaf Merkel, A Thomas Look, Brian J Abraham a Mark W Zimmerman. Cell Reports Medicine. Amsterda: Elsevier, 2024, roč. 5, č. 3, s. 1-20.

doi: 10.1016/j.xcrm.2024.101472. PMID: 38508140

 

Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice. Pavel Fardus, Václav Vybíhal, Ivana Rošková, Iveta Selingerová, Martin Smrčka, Radim Jančálek, Jiří Šána, Ondřej Slabý, Petr Pospíšil, Ludmila Hynková, Jan Garcic, Renata Belanová, Jan Kristek, Andrea Šprláková-Puková, Zdeněk Mackerle, Vilém Juráň, Marek Sova, Eduard Neuman, Hana Valeková, Radek Lakomý, Miloš Holánek, Roman Hrstka, Michaela Švajdová, Kateřina Poláchová, Ivana Koloušková, Pavel Šlampa a Tomáš Kazda. Reports of Practical Oncology and Radiotherapy. Gdansk: Via Medica, 2024, roč. 29, č. 1, s. 30-41. 

doi: 10.5603/rpor.99362.

 

Optimized procedure for high-throughput transcriptome profiling of small extracellular vesicles isolated from low volume serum samples. Petra Vychytilová, Sára Vilmanová, Lucie Pifková, Tina Catela Ivković, Marie Madrzyk, Robin Jugas, Táňa Macháčková, Jan Kotouček, Milana Šachlová, Lucia Bohovicová, Teodor Staněk, Jana Halámková, Igor Kiss a Ondřej Slabý. Clinical Chemistry and Laboratory Medicine. Berlin: Walter De Gruyter, 2024, roč. 62, č. 1, s. 157-167.

doi: 10.1515/cclm-2023-0610. PMID: 37505924

 

ChannelsDB 2.0: a comprehensive database of protein tunnels and pores in AlphaFold era. Anna Špačková, Ondřej Vávra, Tomáš Raček, Václav Bazgier, David Sehnal, Jiří Damborský, Radka Svobodová, David Bednář a Karel Berka. Nucleic Acids Research. Oxford University Press, 2024, roč. 52, D1, s. "D413"-"D418", 6 s. 

doi: 10.1093/nar/gkad1012.

 

ChOP-CT: quantitative morphometrical analysis of the Hindbrain Choroid Plexus by X-ray micro-computed tomography. Viktória Parobková, Petra Kompaníková, Jakub Lázňovský, Michaela Kavková, Marek Hampl, Marcela Buchtová, Tomáš Zikmund, Jozef Kaiser a Vítězslav Bryja. Fluids and Barriers of the CNS. BMC, 2024, roč. 21, č. 1, s. 1-18.

doi: 10.1186/s12987-023-00502-8. PMID: 38268040

 

Orthotopic model for the analysis of melanoma circulating tumor cells. Markéta Pícková, Zuzana Kahounová, Tomasz Witold Radaszkiewicz, Jiřina Procházková, Radek Fedr, Michaela Nosková, Katarzyna Anna Radaszkiewicz, Petra Ovesná, Vítězslav Bryja a Karel Souček. Scientific Reports. Nature Research, 2024, roč. 14, č. 1, s. 1-13.

doi: 10.1038/s41598-024-58236-y.

 

Targeting NRAS via miR-1304-5p or farnesyltransferase inhibition confers sensitivity to ALK inhibitors in ALK-mutant neuroblastoma. Perla Pucci, Liam C Lee, Miaojun Han, Jamie D Matthews, Leila Jahangiri, Michaela Sschlederer, Eleanor Manners, Annabel Sorby-Adams, Joshua Kaggie, Ricky M Trigg, Christopher Steel, Lucy Hare, Emily R James, Nina Prokoph, Stephen P Ducray, Olaf Merkel, Firkret Rifatbegovic, Ji Luo, Sabine Taschner-Mandl, Lukas Kenner, G A Amos Burke a Suzanne Dawn Turner. Nature Communications. Berlin: Nature, 2024, roč. 15, č. 1, s. 1-19. 

doi: 10.1038/s41467-024-47771-x. PMID: 38653965

 

Ligand bias underlies differential signaling of multiple FGFs via FGFR1. Kelly Karl, Del Piccolo Nuala, Taylor Light, Tanaya Roy, Pooja Dudeja, Vlad-Constantin Ursachi, Bohumil Fafílek, Pavel Krejčí a Kalina Hristova. eLife. Cambridge: eLife Sciences Publications Ltd, 2024, roč. 12, April 2024, s. 1-28.

doi: 10.7554/eLife.88144. PMID: 38568193

 

Unveiling the dynamics and molecular landscape of a rare chronic lymphocytic leukemia subpopulation driving refractoriness: insights from single-cell RNA sequencing. Terézia Kurucová, Kamila Réblová, Pavlína Janovská, Jakub Paweł Porc, Veronika Navrkalová, Šárka Pavlová, Jitka Malčíková, Karla Plevová, Boris Tichý, Michael Doubek, Vítězslav Bryja, Jana Kotašková a Šárka Pospíšilová. Molecular oncology. Hoboken: Wiley, 2024, 13 s.

doi: 10.1002/1878-0261.13663. PMID: 38770541

 

In-cell NMR suggests that DNA i-motif levels are strongly depleted in living human cells. Pavlína Víšková, Eva Ištvánková, Jan Ryneš, Šimon Džatko, Tomáš Loja, Martina Lenarčič Živkovic, Riccardo Rigo, Roberto El-Khoury, Israel Serrano-Chacon, Masad J Damha, Carlos Gonzalez, Jean-Louis Mergny, Silvie Trantírková a Lukáš Trantírek. Nature Communications. Berlin: Nature, 2024, roč. 15, č. 1, 12 s.

doi: 10.1038/s41467-024-46221-y. PMID: 38443388

 

MiR-4646-5p Acts as a Tumor-Suppressive Factor in Triple Negative Breast Cancer and Targets the Cholesterol Transport Protein GRAMD1B. Katharina Jonas, Felix Prinz, Manuela Ferracin, Katarina Krajina, Alexander Deutsch, Tobias Madl, Beate Rinner, Ondřej Slabý, Christiane Klec a Martin Pichler. Non-coding RNA. Švýcarsko: MDPI, 2024, roč. 10, č. 1, s. 1-24. 

doi: 10.3390/ncrna10010002. PMID: 38250802 

 

ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia-2024 update. Jitka Malčíková, Šárka Pavlová, Panagiotis Baliakas, Thomas Chatzikonstantinou, Eugen Tausch, Mark Catherwood, Davide Rossi, Thierry Soussi, Boris Tichy, Arnon P Kater, Carsten U Niemann, Frederic Davi, Gianluca Gaidano, Stephan Stilgenbauer, Richard Rosenquist, Kostas Stamatopoulos, Paolo Ghia a Šárka Pospíšilová. Leukemia. London: Nature Publishing Group, 2024, 14 s.

doi: 10.1038/s41375-024-02267-x. PMID: 38755420 

 

PredictONCO: a web tool supporting decision-making in precision oncology by extending the bioinformatics predictions with advanced computing and machine learning. Jan Štourač, Simeon Borko, Rayyan Tariq Khan, Petra Pokorná, Adam Dobiáš, Joan Planas Iglesias, Stanislav Mazurenko, José Gaspar Rangel Pamplona Pizarro Pinto, Veronika Szotkowská, Jaroslav Štěrba, Ondřej Slabý, Jiří Damborský a David Bednář. Briefings in Bioinformatics. Oxford University Press, 2024, roč. 25, č. 1, s. 1-10. 

doi: 10.1093/bib/bbad441. PMID: 38066711

 

A replicating LCMV-based vaccine for the treatment of solid tumors. Purde Mette-Triin, Jovana Cupovic, Yannick A Palmowski, Ahmad Makky, Sarah Schmidt, Alexander Rochwarger, Fabienne Hartmann, Felix Stemeseder, Alexander Lercher, Abdou Marie-Therese, David Bomze, Lenka Bešše, Fiamma Berner, Thomas Tüting, Michael Hölzel, Andreas Bergthaler, Stefan Kochanek, Burkhard Ludewig, Henning Lauterbach, Klaus K Orlinger, Tobias Bald, Andrea Schietinger, Christian Schürch, Sandra S Ring a Lukas Flatz. Molecular Therapy. Cambridge: Cell Press, 2024, roč. 32, č. 2, s. 426-439.

doi: 10.1016/j.ymthe.2023.11.026. PMID: 38058126

 

A sodium/potassium switch for G4-prone G/C-rich sequences. Yu Luo, Martina Lenarčič Živkovic, Jiawei Wang, Jan Ryneš, Silvie Trantírková, Lukáš Trantírek, Daniela Verga a Jean-Louis Mergny. Nucleic acids research. Oxford: Oxford University Press, 2024, roč. 52, č. 1, s. 448-461.

doi: 10.1093/nar/gkad1073. PMID: 37986223 

 

Global interactome mapping reveals pro-tumorigenic interactions of NF-κB in breast cancer. Petr Lapčík, R. Greg Stacey, David Potěšil, Petr Kulhánek, Leonard J. Foster a Pavel Bouchal. Molecular and Cellular Proteomics. Elsevier, 2024, roč. 23, č. 4, s. 1-20.

doi: 10.1016/j.mcpro.2024.100744. PMID: 38417630 

 

Why are not all eligible chronic myeloid leukemia patients willing to attempt tyrosine kinase inhibitor discontinuation? A Czech nationwide analysis related to the TKI stopping trial HALF. Daniela Žáčková, Lukáš Semerád, Edgar Faber, Hana Klamová, Lukáš Stejskal, Petra Bělohlávková, Michal Karas, Eduard Cmunt, Olga Černá, Jiřina Procházková, Petra Čičátková, Anežka Kvetková, Tomáš Horňák, Ivana Skoumalová, Dana Srbová, Cyril Šálek, David Buffa, Jaroslava Voglová, Tomáš Jurček, Adam Folta, Ivana Ježíšková, Hana Žižková, Kateřina Machová Poláková, Tomáš Papajík, Pavel Žák, Pavel Jindra, Adam Svobodník, Radka Štěpánová a Jiří Mayer. Leukemia. London: Springer Nature, 2024, roč. 38, č. 4, s. 893-897.

doi: 10.1038/s41375-024-02215-9. PMID: 38472478 

 

Unilateral hippocampal sparing during whole brain radiotherapy for multiple brain metastases: narrative and critical review. Petr Pospíšil, Ludmila Hynková, Lucie Hnidáková, Jana Maistryszinová, Pavel Šlampa a Tomáš Kazda. Frontiers in Oncology. Lausanne: Frontiers Media SA, 2024, roč. 14, January 2024, s. 1-11.

doi: 10.3389/fonc.2024.1298605. PMID: 38327742

 

Hippocampal subfield volumetric changes after radiotherapy for brain metastases. Klára Holíková, Iveta Selingerova, Petr Pospíšil, Martin Bulik, Ludmila Hynková, Ivana Kolouskova, Lucie Hnidakova, Petr Burkoň, Marek Slávik, Jiří Šána, Tomáš Holeček, Jiří Vaníček, Pavel Šlampa, Radim Jančálek a Tomáš Kazda. Neuro-Oncology Advances. Oxford: Oxford Univ Press, 2024, roč. 6, č. 1, 9 s. 

doi: 10.1093/noajnl/vdae040. PMID: 38645488 

 

Investigation of long non-coding RNAs in extracellular vesicles from low-volume blood serum specimens of colorectal cancer patients. Marie Boudná, Táňa Macháčková, Petra Vychytilová, Karolína Trachtová, Renata Bartošová, Tina Catela Ivković, Dagmar Al Tukmachi, Robin Jugas, Lucie Pifková, Jana Orlíčková, Jan Kotouček, Marketa Pavlikova, Milana Šachlová, Lucia Bohovicová, Teodor Staněk, Jana Halámková, Igor Kiss, Tomáš Grolich, Martin Svoboda, Zdeněk Kala, Kamila Součková a Ondřej Slabý. Clinical and Experimental Medicine. Milan: Springer-Verlag Italia SRL, 2024, roč. 24, č. 1, s. 1-14.

doi: 10.1007/s10238-024-01323-1. PMID: 38568288

 

Real-world data on diagnostics, treatment and outcomes of patients with hairy cell leukemia: The HCL-CLLEAR study. Anna Panovská, Pavel Zak, Tereza Jurkova, Tomáš Arpáš, Yvona Brychtová, Alžběta Vašíčková, Viera Hrabáčková, Adéla Prchlíková, Martina Filipová a Michael Doubek. Hematological Oncology. Hoboken: Wiley-Blackwell, 2024, roč. 42, č. 3, s. 1-9.

doi: 10.1002/hon.3280. PMID: 38741354

 

IκBε deficiency accelerates disease development in chronic lymphocytic leukemia. Jessica Bordini, Chiara Lenzi, Michela Frenquelli, Alessia Morabito, Athanasios Pseftogas, Daniela Belloni, Larry Mansouri, George Tsiolas, Eleonora Perotta, Pamela Ranghetti, Francesca Gandini, Francesca Genova, Daniel Hagerstrand, Georgios Gavriilidis, Sofoklis Keisaris, Nikolaos Pechlivanis, Frederic Davi, Neil E Kay, Anton W Langerak, Šárka Pospíšilová, Lydia Scarfo, Antonios Makris, Fotis E Psomopoulos, Kostas Stamatopoulos, Richard Rosenquist, Alessandro Campanella a Paolo Ghia. Leukemia. London: Nature Publishing Group, 2024, 12 s.

doi: 10.1038/s41375-024-02236-4. 

 

Precision immuno-oncology approach for four malignant tumors in siblings with constitutional mismatch repair deficiency syndrome. Hana Pálová, Anirban Das, Petra Pokorná, Viera Bajčiová, Zdenek Pavelka, Marta Ježová, Karol Pál, Jose R Dimayacyac, Logine Negm, Lucie Stengs, Vanessa Bianchi, Klára Vejmělková, Kristýna Nosková, Marie Jarošová, Soňa Mejstříková, Peter Múdry, Michal Kýr, Tomáš Merta, Pavel Tinka, Klára Drábová, Štefánia Aulická, Robin Jugas, Uri Tabori, Ondřej Slabý a Jaroslav Štěrba. NPJ Precision Oncology. Belin: Nature Portfolio, 2024, roč. 8, č. 1, s. 1-9.

doi: 10.1038/s41698-024-00597-8.

 

Strategies for labelling of exogenous and endogenous extracellular vesicles and their application for in vitro and in vivo functional studies. Marie Boudná, Andres Delgado Campos, Petra Vychytilová, Táňa Macháčková, Ondřej Slabý a Kamila Součková. Cell Communication and Signaling. London: BMC, 2024, roč. 22, č. 1, s. 1-15.

doi: 10.1186/s12964-024-01548-3. PMID: 38461237

 

Toxicity of external beam accelerated partial-breast irradiation (APBI) in adjuvant therapy of early-stage breast cancer: prospective randomized study. Petr Burkoň, Iveta Selingerová, Marek Slávik, Miloš Holánek, Miroslav Vrzal, Oldřich Coufal, Kateřina Poláchová, Petr Müller, Pavel Šlampa a Tomáš Kazda. Radiation Oncology. BMC: Elsevier, 2024, roč. 19, č. 1, s. 1-12.

doi: 10.1186/s13014-024-02412-x. PMID: 38310249

 

FasL impacts Tgfb signaling in osteoblastic cells. Adela Kratochvilova, Lucia Knopfová, Janka Gregorkova, Reinhard Gruber, Eva Janeckova, Yang Chai a Eva Matalova. Cells & Development. Elsevier B.V., 2024, 6 s.

doi: 10.1016/j.cdev.2024.203929. PMID: 38810946

 

InVADo: Interactive Visual Analysis of Molecular Docking Data. Marco Schäfer, Nicolas Brich, Jan Byška, Sérgio Manuel Marques, David Bednář, Philipp Thiel, Barbora Kozlíková a Michael Krone. IEEE Transactions on Visualization and Computer Graphics. IEEE Computer Society, 2024, roč. 30, č. 4, s. 1984-1997.

doi: 10.1109/TVCG.2023.3337642. PMID: 38019636

 

Caspase-9 Is a Positive Regulator of Osteoblastic Cell Migration Identified by diaPASEF Proteomics. Kamila Říhová, Petr Lapčík, Barbora Veselá, Lucia Knopfová, David Potěšil, Jana Pokludová, Jan Šmarda, Eva Matalová, Pavel Bouchal a Petr Beneš. Journal of Proteome Research. American Chemical Society, 2024, 13 s.

doi: 10.1021/acs.jproteome.3c00641. PMID: 38498986

 

Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease. Petr Pleskač, Christine A. Fargeas, Renata Veselská, Denis Corbeil a Jan Škoda. Cellular and Molecular Biology Letters. BMC, 2024, roč. 29, č. 1, s. 1-47.

doi: 10.1186/s11658-024-00554-0. PMID: 38532366

 

Challenges with hippocampal MR spectroscopy as a surrogate for pre-radiotherapy assessment of neurocognitive impairment in patients with brain metastasis. Iveta Selingerová, Klára Holíková, Tomas Chodur, Ludmila Hynková, Petr Pospíšil, Martin Bulik, Renata Belanová, Kamila Siffelova, Ivana Koloušková, Marek Slávik, Petr Burkoň, Roman Hrstka, Radim Jančálek, Jiří Šána, Pavel Šlampa a Tomáš Kazda. Biomedical Papers, Olomouc: Palacky University. Olomouc: Palacky University, 2024, 8 s.

doi: 10.5507/bp.2024.012. PMID: 38623639 

 

Blockage of BCL-XL overcomes venetoclax resistance across BCL2-positive lymphoid malignancies irrespective of BIM status. Alexandra Dolnikova, Dmitry Kazanstev, Magdalena Klanova, Eva Pokorna, Dana Sovilj, Cristina Daniela Kelemen, Liliana Tuskova, Eva Hoferková, Marek Mráz, Karel Helman, Nikola Curik, Katerina Machova Polakova, Ladislav Anděra, Marek Trněný a Pavel Klener. Blood Advances. Amsterdam: Elsevier, 2024, roč. 10.1182/bl.

doi: 10.1182/bloodadvances.2024012906. PMID: 38713893

 

Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drug. Eva Hoferková, Václav Šeda, Soňa Cesnáriková, Jan Verner, Tomáš Loja, Květoslava Matulová, Hana Skuhrová Francová, Eva Ondroušková, Daniel Filip, Nicolas Blavet, Miroslav Boudný, Gabriela Mladonická Pavlasová, Josef Večeřa, Laura Ondrišová, Petra Pavelková, Kryštof Hlaváč, Lenka Košťálová, Androniki Michaelou, Šárka Pospíšilová, Jana Dorazilová, Václav Chochola, Josef Jaroš, Michael Doubek, Marie Jarošová, Aleš Hampl, Lucy Vojtová, Leoš Křen, Jiří Mayer a Marek Mráz. Leukemia. London: Springer Nature, 2024.

doi: 10.1038/s41375-024-02284-w. PMID: 38877102

Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development. Jaydev Dave, Vineeta Jagana, Radoslav Janostiak, Malik Bisserier. J Transl Med. 2023 Jul 17;21(1):477.

doi: 10.1186/s12967-023-04339-5. PMID: 37461108; PMCID: PMC10353122.

 

Sequencing-based analysis of clonal evolution of 25 mantle cell lymphoma patients at diagnosis and after failure of standard immunochemotherapy. Jana Karolová, Dmitry Kazantsev, Michael Svatoň, Liliana Tušková, Kristina Forsterová, Diana Maláriková, Kateřina Benešová, Tomáš Heizer, Alexandra Dolníková, Magdalena Klánová, Lucie Winkowska, Karla Svobodová, Jan Hojný, Eva  Krkavcová, Eva Froňková, Zuzana Zemanová, Marek Trněný, Pavel Klener. Am J Hematol. 2023; 98(10): 1627-1636.

doi:10.1002/ajh.27044. PMID: 37605345

 

Early-Onset Ovarian Cancer <30 Years: What Do We Know about Its Genetic Predisposition? Klara Horackova, Marketa Janatova, Petra Kleiblova, Zdenek Kleibl and Jana Soukupova. Int J Mol Sci. 2023 Nov 30;24(23):17020.

doi: 10.3390/ijms242317020. PMID: 38069345; PMCID: PMC10707471.

 

Total neoadjuvant therapy in rectal cancer: the evidence and expectations. Ludmila Boublikova, Alena Novakova, Jaromir Simsa, Radka Lohynska. Critical Reviews in Oncology/hematology. 2023 Dec;192:104196.

doi: 10.1016/j.critrevonc.2023.104196. PMID: 37926376.

 

Combination of quinoxaline with pentamethinium system: Mitochondrial staining and targeting. Zdeněk Kejík, Nela Koubková, Lucie Krčová, David Sýkora, Nikita Abramenko, Kateřina Veselá, Robert Kaplánek, Jan Hajduch, Magdalena Houdová Megová, Petr Bušek, Aleksi Šedo, Lukáš Lacina, Karel Smetana Jr., Pavel Martásek, Milan Jakubek. Bioorg Chem. 2023 Dec;141:106816.

doi: 10.1016/j.bioorg.2023.106816. PMID: 37716274.

 

TET protein inhibitors: Potential and limitations. Robert Kaplánek, Zdeněk Kejík, Jan Hajduch, Kateřina Veselá, Kateřina Kučnirová, Markéta Skaličková, Anna Venhauerová, Božena Hosnedlová, Róbert Hromádka, Petr Dytrych, Petr Novotný, Nikita Abramenko, Veronika Antonyová, David Hoskovec, Petr Babula, Michal Masařík, Pavel Martásek, Milan Jakubek.. Biomed Pharmacother. 2023 Oct;166:115324.

doi: 10.1016/j.biopha.2023.115324. PMID: 37598475.

 

Fibroblast activation protein as a potential theranostic target in brain metastases of diverse solid tumours. Michal Zubaľ, Barbora Výmolová, Ivana Matrasová, Petr Výmola, Jana Vepřková, Martin Syrůček, Robert Tomáš, Zdislava Vaníčková, Evžen Křepela, Dora Konečná, Petr Bušek, Aleksi Šedo. Pathology. 2023 Oct;55(6):806-817.

doi: 10.1016/j.pathol.2023.05.003. PMID: 37419841.

 

Tuning polymer-blood and polymer-cytoplasm membrane interactions by manipulating the architecture of poly(2-oxazoline) triblock copolymers. Volodymyr Lobaz, Veronika Liščáková, František Sedlák, Dominik Musil, Svetlana Lukáš Petrova, Ivana Šeděnková, Jiří Pánek, Jan Kučka, Rafał Konefał, Eva Tihlaříková, Vilém Neděla, Jan Pankrác, Luděk Šefc, Martin Hrubý, Pavel Šácha, Petr Štěpánek. Colloids Surf B Biointerfaces. 2023 Nov; 231:113564.

doi: 10.1016/j.colsurfb.2023.113564. PMID: 37742364.

 

Dual detection system for cancer-associated point mutations assisted by a multiplexed LNA-based amperometric bioplatform coupled with rolling circle amplification, Ravery Sebuyoya, Alejandro Valverde, Ludmila Moranova, Johana Strmiskova, Roman Hrstka, Víctor Ruiz-Valdepeñas Montiel, José M. Pingarrón, Rodrigo Barderas, Susana Campuzano, Martin Bartosik. Sensors and Actuators B: Chemical, Volume 394, 2023, 134375.

doi: 10.1016/j.snb.2023.134375.

 

Primary assessment of medicines for expected migrastatic potential with holographic incoherent quantitative phase imaging. Markéta Šuráňová, Miroslav Ďuriš, Irena Štenglová Netíková, Jan Brábek, Tomáš Horák, Veronika Jůzová, Radim Chmelík, Pavel Veselý. Biomed Opt Express. 2023 May 16;14(6):2689-2708.

doi: 10.1364/BOE.488630. PMID: 37342686; PMCID: PMC10278600.

 

Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase. Lenka Koudelková, Markéta Pelantová, Zuzana Brůhová, Martin Sztacho, Vojtěch Pavlík, Dalibor Pánek, Jakub Gemperle, Pavel Talacko, Jan Brábek, Daniel Rösel. Elife. 2023 Jul 10;12:e82428.

doi: 10.7554/eLife.82428. PMID: 37428018; PMCID: PMC10361714.

 

Th1/interferon-γ bias in 22q11.2 deletion syndrome is driven by memory T cells and exacerbated by IL-7. Ondrej Vladyka, Petra Vrabcova, Michaela Reiterova, Zuzana Parackova, Robert Haesler, Anna Sediva, Tomas Kalina, Adam Klocperk. Clin Immunol. 2023 Nov; 256:109793.

doi: 10.1016/j.clim.2023.109793. PMID: 37776967.

 

Posttreatment positivity of BCR::ABL1 in acute lymphoblastic leukemia: Should we keep track? Jan Zuna, Lenka Hovorkova, Justina Krotka, Lucie Winkowska, Zbynek Novak, Lucie Sramkova, Jan Stary, Jan Trka, Giovanni Cazzaniga, Gunnar Cario, Marketa Zaliova. Am J Hematol. 2023 Oct;98(10):E269-E271.

doi: 10.1002/ajh.27022. PMID: 37449465.

 

Chimeric JAK2 Kinases Trigger Non-uniform Changes of Cellular Metabolism in BCR-ABL1-like Childhood ALL. Julius Lukes Jr, Eliska Potuckova, Natividad Alquezar-Artieda, Ivana Hermanova, Sladjana Kosanovic, Katerina Hlozkova, Meritxell Alberich Jorda, Jan Zuna, Jan Trka, Daniel A Tennant, Martin Stanulla, Marketa Zaliova, Julia Starkova. Hemasphere. 2023 Aug 23;7(9):e946.

doi: 10.1097/HS9.0000000000000946. PMID: 37637992; PMCID: PMC10448929.

 

Hybrid Macromolecular Constructs as a Platform for Spectral Nanoprobes for Advanced Cellular Barcoding in Flow Cytometry. Júlia Kudláčová, Daniela Kužílková, František Bárta, Naděžda Brdičková, Adéla Vávrová, Libor Kostka, Ondřej Hovorka, Tomáš Kalina, Tomáš Etrych. Macromol Biosci. 2023 Sep 11:e2300306.

doi: 10.1002/mabi.202300306. PMID: 37691533.

 

Survival in melanoma in the nordic countries into the era of targeted and immunological therapies. Filip Tichanek, Asta Försti, Akseli Hemminki, Otto Hemminki, Kari Hemminki. Eur J Cancer. 2023 Jun;186:133-141.

doi: 10.1016/j.ejca.2023.03.019. PMID: 37068406; PMCID: PMC10209636.

 

Survival in Lung Cancer in the Nordic Countries Through A Half Century. Filip Tichanek, Asta Försti, Otto Hemminki, Akseli Hemminki, Kari Hemminki. Clin Epidemiol. 2023 May 1;15:503-510.

doi: 10.2147/CLEP.S406606. PMID: 37153073; PMCID: PMC10162394.

 

The dynamics of telomere length in primary and metastatic colorectal cancer lesions. Michal Kroupa, Ondrej Kubecek, Kristyna Tomasova, Petr Hanak, Marketa Krupova, Klara Cervena, Anna Siskova, Jachym Rosendorf, Petr Hosek , Ludmila Vodickova, Pavel Vodicka, Vaclav Liska, Stanislav John, Veronika Vymetalkova, Jiri Petera. Sci Rep. 2023 Jun 5;13(1):9097.

doi: 10.1038/s41598-023-35835-9. PMID: 37277368; PMCID: PMC10241861.

 

A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study. Barbara Pardini, Giulio Ferrero, Sonia Tarallo, Gaetano Gallo, Antonio Francavilla, Nicola Licheri, Mario Trompetto, Giuseppe Clerico, Carlo Senore, Sergio Peyre, Veronika Vymetalkova, Ludmila Vodickova, Vaclav Liska, Ondrej Vycital, Miroslav Levy, Peter Macinga, Tomas Hucl, Eva Budinska, Pavel Vodicka, Francesca Cordero, Alessio Naccarati. Gastroenterology. 2023 Sep;165(3):582-599.e8.

doi: 10.1053/j.gastro.2023.05.037. PMID: 37263306.

 

Autoimmune diseases as comorbidities for liver, gallbladder, and biliary duct cancers in Sweden. Kari Hemminki, Kristina Sundquist, Jan Sundquist, Asta Försti, Vaclav Liska, Akseli Hemminki, Xinjun Li. Cancer. 2023 Jan 30.

doi: 10.1002/cncr.34663. PMID: 36715017.

 

Type I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients. Peter Holicek, Iva Truxova, Jana Rakova, Cyril Salek, Michal Hensler, Marek Kovar, Milan Reinis, Romana Mikyskova, Josef Pasulka, Sarka Vosahlikova, Hana Remesova, Iva Valentova, Daniel Lysak, Monika Holubova, Petr Kaspar, Jan Prochazka, Lenka Kasikova, Radek Spisek, Lorenzo Galluzzi, Jitka Fucikova. Cell Death Dis. 2023 Mar 24;14(3):209.

doi: 10.1038/s41419-023-05728-w. PMID: 36964168; PMCID: PMC10039058.

 

Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2. Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek. Elife. 2023 Jan 27;12:e79342.

doi: 10.7554/eLife.79342. PMID: 36705564; PMCID: PMC9977273.

 

IL-2-driven CD8+ T cell phenotypes: implications for immunotherapy. Veronika Niederlova, Oksana Tsyklauri, Marek Kovar, Ondrej Stepanek. Trends Immunol. 2023 Nov;44(11):890-901.

doi: 10.1016/j.it.2023.09.003. PMID: 37827864; PMCID: PMC7615502.

 

Antifouling Properties of Poly(2-Oxazoline)s and Poly(2-Oxazine)s: Direct Comparison of Polymer-Coated Surfaces with the Same Coating Parameters. Jan Svoboda, Niccolo Lusiani, Radoslava Sivkova, Ognen Pop-Georgievski, Ondrej Sedlacek. Macromol Rapid Commun. 2023 Sep;44(17):e2300168.

doi: 10.1002/marc.202300168. PMID: 37220400.

 

Hydrophilic Copolymers with Hydroxamic Acid Groups as a Protective Biocompatible Coating of Maghemite Nanoparticles: Synthesis, Physico-Chemical Characterization and MRI Biodistribution Study. Hana Charvátová, Zdeněk Plichta, Jiřina Hromádková, Vít Herynek, Michal Babič. Pharmaceutics. 2023 Jul 19;15(7):1982.

doi: 10.3390/pharmaceutics15071982. PMID: 37514168; PMCID: PMC10384990.

 

Polyelectrolyte nanoparticles based on poly[N-(2-hydroxypropyl)methacrylamide-block-poly(N-(3-aminopropyl)methacrylamide] copolymers for delivery of heparin-binding proteins. Gabriela S. García-Briones, Richard Laga, Zulfiya Černochová, Carely Arjona-Ruiz, Olga Janoušková, Miroslav Šlouf, Ognen Pop-Georgievski, Dana Kubies.  European Polymer Journal, Volume 191, 2023, 111976, ISSN 0014-3057.

doi: 10.1016/j.eurpolymj.2023.111976.

 

Singlet Oxygen In Vivo: It Is All about Intensity-Part 2. Steffen Hackbarth, Shanghui Gao, Vladimír Šubr, Lisheng Lin, Jakob Pohl, Tomáš Etrych, Jun Fang. J Pers Med. 2023 Apr 30;13(5):781.

doi: 10.3390/jpm13050781. PMID: 37240951; PMCID: PMC10222680.

 

Adaptable polymerization platform for therapeutics with tunable biodegradability. Hrochová M, Kotrchová L, Frejková M, Konefał R, Gao S, Fang J, Kostka L, Etrych T. Acta Biomater. 2023 Nov;171:417-427.

doi: 10.1016/j.actbio.2023.09.004. PMID: 37696413.

 

Stimuli-Responsive Polymer Nanoprobes Intended for Fluorescence-Guided Surgery of Malignant Head-and-Neck Tumors and Metastases. Robert Pola, Eliška Grosmanová, Michal Pechar, Dominik Horák, Tereza Krunclová, Jan Pankrác, Maxime Henry, Martin Kaňa, Jan Bouček, Luděk Šefc, Jean-Luc Coll, Tomáš Etrych. Adv Healthc Mater. 2023 Nov;12(28):e2301183.

doi: 10.1002/adhm.202301183. PMID: 37288946.

 

Polymer theranostics with multiple stimuli-based activation of photodynamic therapy and tumor imaging. Marina Rodrigues Tavares, Rayhanul Islam, Vladimír Šubr, Steffen Hackbarth, Shanghui Gao, Kai Yang, Volodymyr Lobaz, Jun Fang, Tomáš Etrych. Theranostics. 2023 Sep 4;13(14):4952-4973.

doi: 10.7150/thno.86211. PMID: 37771769; PMCID: PMC10526675.

 

The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer. Daniele Campa, Manuel Gentiluomo, Angelika Stein, Mateus Nóbrega Aoki, Martin Oliverius, Ludmila Vodičková, Krzysztof Jamroziak, George Theodoropoulos, Claudio Pasquali, William Greenhalf, Paolo Giorgio Arcidiacono, Faik Uzunoglu, Raffaele Pezzilli, Claudio Luchini, Marta Puzzono, Martin Loos, Matteo Giaccherini, Verena Katzke, Andrea Mambrini, Edita Kiudeliene, Kauffmann Emanuele Federico, Julia Johansen, Tamás Hussein, Beatrice Mohelnikova-Duchonova, Casper H J van Eijck, Hermann Brenner, Riccardo Farinella, Juan Sainz Pérez, Martin Lovecek, Markus W Büchler, Viktor Hlavac, Jakob R Izbicki, Thilo Hackert, Roger Chammas, Alessandro Zerbi, Rita Lawlor, Alessio Felici, Mara Götz, Gabriele Capurso, Laura Ginocchi, Maria Gazouli, Juozas Kupcinskas, Giulia Martina Cavestro, Pavel Vodicka, Stefania Moz, John P Neoptolemos, Lumir Kunovsky, Stig E Bojesen, Silvia Carrara, Domenica Gioffreda, Egidijus Morkunas, Olga Abian, Stefania Bunduc, Daniela Basso, Ugo Boggi, Barbara Wlodarczyk, Andrea Szentesi, Giuseppe Vanella, Inna Chen, Maarten F Bijlsma, Vytautas Kiudelis, Stefano Landi, Ben Schöttker, Chiara Corradi, Nathalia Giese, Rudolf Kaaks, Giulia Peduzzi, Péter Hegyi, Luca Morelli, Niccolò Furbetta, Pavel Soucek, Anna Latiano, Renata Talar-Wojnarowska, Sidsel C Lindgaard, Frederike Dijk, Anna Caterina Milanetto, Francesca Tavano, Klara Cervena, Bálint Erőss, Sabrina G Testoni, Judith H E Verhagen-Oldenampsen, Ewa Małecka-Wojciesko, Eithne Costello, Roberto Salvia, Evaristo Maiello, Stefano Ermini, Cosimo Sperti, Bernd Holleczek, Francesco Perri, Jurgita Skieceviciene, Livia Archibugi, Maurizio Lucchesi, Cosmeri Rizzato, Federico Canzian. Crit Rev Oncol Hematol. 2023 Jun;186:104020.

doi: 10.1016/j.critrevonc.2023.104020. PMID: 37164172.

 

Mitochondrially targeted tamoxifen in patients with metastatic solid tumours: an open-label, phase I/Ib single-centre trial. Zuzana Bielcikova, Jan Stursa, Ludmila Krizova, Lanfeng Dong, Jan Spacek, Stanislav Hlousek, Michal Vocka, Katerina Rohlenova, Olga Bartosova, Vladimir Cerny, Tomas Padrta, Michal Pesta, Pavel Michalek, Sona Stemberkova Hubackova, Katarina Kolostova, Eliska Pospisilova, Vladimir Bobek, Peter Klezl, Renata Zobalova, Berwini Endaya, Jakub Rohlena, Lubos Petruzelka, Lukas Werner, Jiri Neuzil. EClinicalMedicine. 2023 Feb 23;57:101873.

doi: 10.1016/j.eclinm.2023.101873. PMID: 37064512; PMCID: PMC10102891.

 

Targeting Prostate Cancer Using Bispecific T-Cell Engagers against Prostate-Specific Membrane Antigen. Gargi Das, Jakub Ptacek, Barbora Havlinova, Jana Nedvedova, Cyril Barinka, Zora Novakova. ACS Pharmacol Transl Sci. 2023 Oct 6;6(11):1703-1714.

doi: 10.1021/acsptsci.3c00159. PMID: 37974624.

 

Frentizole derivatives with mTOR inhibiting and senomorphic properties. Zofia Chrienova, David Rysanek, Josef Novak, Pavla Vasicova, Patrik Oleksak, Rudolf Andrys, Adam Skarka, Jelena Dumanovic, Zoran Milovanovic, Vesna Jacevic, Marketa Chvojkova, Kristina Holubova, Karel Vales, Veronika Skoupilova, Marian Valko, Klaudia Jomova, Suliman Y Alomar, Fernanda D Botelho, Tanos C C Franca, Kamil Kuca, Zdenek Hodny, Eugenie Nepovimova. Biomed Pharmacother. 2023 Nov;167:115600.

doi: 10.1016/j.biopha.2023.115600. PMID: 37783152.

 

Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members. Linda Berková, Hassan Fazilaty, Qiutan Yang, Jan Kubovčiak, Monika Stastna, Dusan Hrckulak, Martina Vojtechova, Tosca Dalessi, Michael David Brügger, George Hausmann, Prisca Liberali, Vladimir Korinek, Konrad Basler, Tomas Valenta. EMBO Rep. 2023 Sep 6;24(9):e56454.

doi: 10.15252/embr.202256454. PMID: 37493498; PMCID: PMC10481656.

 

Ppm1d truncating mutations promote the development of genotoxic stress-induced AML. Monika Burocziova, Petr Danek, Anna Oravetzova, Zuzana Chalupova, Meritxell Alberich-Jorda, Libor Macurek. Leukemia. 2023 Nov;37(11):2209-2220.

doi: 10.1038/s41375-023-02030-8. PMID: 37709843; PMCID: PMC10624630.

 

ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk. Lenka Stolarova, Petra Kleiblova, Petra Zemankova, Barbora Stastna, Marketa Janatova, Jana Soukupova, Maria Isabel Achatz, Christine Ambrosone, Paraskevi Apostolou, Banu K Arun, Paul Auer, Mollie Barnard, Birgitte Bertelsen; Biobank Japan; Marinus J Blok, Nicholas Boddicker, Joan Brunet, Elizabeth S Burnside, Mariarosaria Calvello, Ian Campbell, Sock Hoai Chan, Fei Chen, Jian Bang Chiang, Anna Coppa, Laura Cortesi, Ana Crujeiras-González; Consortium CZECANCA; Kim De Leeneer, Robin De Putter, Allison DePersia, Lisa Devereux, Susan Domchek, Anna Efremidis, Christoph Engel, Corinna Ernst, D Gareth R Evans, Lidia Feliubadaló, Florentia Fostira, Olivia Fuentes-Ríos, Encarna B Gómez-García, Sara González, Christopher Haiman, Thomas van Overeem Hansen, Jan Hauke, James Hodge, Chunling Hu, Hongyan Huang, Nur Diana Binte Ishak, Yusuke Iwasaki, Irene Konstantopoulou, Peter Kraft, James Lacey, Conxi Lázaro, Na Li, Weng Khong Lim, Sara Lindstrom, Adriana Lori, Elana Martinez, Alexandra Martins, Koichi Matsuda, Giuseppe Matullo, Simone McInerny, Kyriaki Michailidou, Marco Montagna, Alvaro N A Monteiro, Luigi Mori, Katherine Nathanson, Susan L Neuhausen, Heli Nevanlinna, Janet E Olson, Julie Palmer, Barbara Pasini, Alpa Patel, Maria Piane, Bruce Poppe, Paolo Radice, Alessandra Renieri, Nicoletta Resta, Marcy E Richardson, Toon Rosseel, Kathryn J Ruddy, Marta Santamariña, Elizabeth Santana Dos Santos, Lauren Teras, Amanda E Toland, Amy Trentham-Dietz, Celine M Vachon, Alexander E Volk, Nana Weber-Lassalle, Jeffrey N Weitzel, Lisa Wiesmuller, Stacey Winham, Siddhartha Yadav, Drakoulis Yannoukakos, Song Yao, Valentina Zampiga, Magnus Zethoven, Ze Wen Zhang, Tomas Zima, Amanda B Spurdle, Ana Vega, Maria Rossing, Jesús Del Valle, Arcangela De Nicolo, Eric Hahnen, Kathleen B M Claes, Joanne Ngeow, Yukihide Momozawa, Paul A James, Fergus J Couch, Libor Macurek, Zdenek Kleibl. Clin Cancer Res. 2023 Aug 15;29(16):3037-3050.

doi: 10.1158/1078-0432.CCR-23-0212. PMID: 37449874; PMCID: PMC10425727.

 

Chronic inflammation promotes cancer progression as a second hit. Monika Burocziova, Srdjan Grusanovic, Karolina Vanickova, Sladjana Kosanovic, Meritxell Alberich-Jorda. Exp Hematol. 2023 Dec;128:30-37.

doi: 10.1016/j.exphem.2023.09.002. PMID: 37709251.

 

Hematopoietic stem cells undergo a lymphoid to myeloid switch in early stages of emergency granulopoiesis. Karolina Vanickova, Mirko Milosevic, Irina Ribeiro Bas, Monika Burocziova, Asumi Yokota, Petr Danek, Srdjan Grusanovic, Mateusz Chiliński, Dariusz Plewczynski, Jakub Rohlena, Hideyo Hirai, Katerina Rohlenova, Meritxell Alberich-Jorda. EMBO J. 2023 Dec 1;42(23):e113527.

doi: 10.15252/embj.2023113527. PMID: 37846891; PMCID: PMC10690458.

 

Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-l-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery. Kateřina Novotná, Lukáš Tenora, Eva Prchalová, James Paule, Jesse Alt, Vijay Veeravalli, Jenny Lam, Ying Wu, Ivan Šnajdr, Sadakatali Gori, Vijaya Saradhi Mettu, Takashi Tsukamoto, Pavel Majer, Barbara S Slusher, Rana Rais. J Med Chem. 2023 Nov 23;66(22):15493-15510.

doi: 10.1021/acs.jmedchem.3c01681. PMID: 37949450; PMCID: PMC10683027.

 

Randomizing for Alzheimer's disease drug trials should consider the cancer history of participants. Viswanath Das, Marián Hajdúch. Brain. 2023 Oct 3;146(10):e75-e76.

doi: 10.1093/brain/awad177. PMID: 37243427.

 

Drug-Drug Interactions of Cannabidiol with Standard-of-Care Chemotherapeutics. Tereza Buchtova, David Lukac, Zdenek Skrott, Katarina Chroma, Jiri Bartek, Martin Mistrik. Int J Mol Sci. 2023 Feb 2;24(3):2885.

doi: 10.3390/ijms24032885. PMID: 36769206; PMCID: PMC9917508.

 

Increased blood reactive oxygen species and hepcidin in obstructive sleep apnea precludes expected erythrocytosis. Jihyun Song, Krishna M Sundar, Monika Horvathova, Radhika Gangaraju, Karel Indrak, Robert D Christensen, Samuel Genzor, Carsten Lundby, Vladimir Divoky, Tomas Ganz, Josef T Prchal. Am J Hematol. 2023 Aug;98(8):1265-1276.

doi: 10.1002/ajh.26992. PMID: 37350302.

 

2,4-Diaryl-pyrimido[1,2-a]benzimidazole derivatives as novel anticancer agents endowed with potent anti-leukemia activity: Synthesis, biological evaluation and kinase profiling. Moataz A Shaldam, Denisa Hendrychová, Radwan El-Haggar, Veronika Vojáčková, Taghreed A Majrashi, Eslam B Elkaeed, Nicolas Masurier, Vladimír Kryštof, Haytham O Tawfik, Wagdy M Eldehna. Eur J Med Chem. 2023 Oct 5;258:115610.

doi: 10.1016/j.ejmech.2023.115610. PMID: 37437350.

 

A unique case of AH-dominant type nodular pulmonary amyloidosis presenting as a spontaneous pneumothorax: a case report and review of the literature. Valeria Skopelidou, Pavel Hurník, Lubomír Tulinský, Vladimir Židlík, Jiří Lenz, Patricie Delongová, Helena Hornychová, Patrik Flodr, Tomáš Jelínek, Ludmila Muroňová, Dušan Holub, Petr Džubák, Marián Hajdúch. Pathol Oncol Res. 2023 Sep 22;29:1611390.

doi: 10.3389/pore.2023.1611390. PMID: 37808084; PMCID: PMC10556250.

 

Circulating tumor cell-derived preclinical models: current status and future perspectives. Zuzana Kahounová, Markéta Pícková, Stanislav Drápela, Jan Bouchal, Eva Szczyrbová, Jiří Navrátil, Karel Souček. Cell Death Dis. 2023 Aug 17;14(8):530.

doi: 10.1038/s41419-023-06059-6. PMID: 37591867; PMCID: PMC10435501.

 

Discrimination of resected glioma tissues using surface enhanced Raman spectroscopy and Au@ZrO2 plasmonic nanosensor. Vaclav Ranc, Ondrej Pavlacka, Ondrej Kalita, Miroslav Vaverka. Spectrochim Acta A Mol Biomol Spectrosc. 2024 Jan 15;305:123521.

doi: 10.1016/j.saa.2023.123521. PMID: 37862838.

 

Nucleoside-based anticancer drugs: Mechanism of action and drug resistance. Lenka Hruba, Viswanath Das, Marian Hajduch, Petr Dzubak. Biochem Pharmacol. 2023 Sep;215:115741.

doi: 10.1016/j.bcp.2023.115741. PMID: 37567317.

 

Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus. Maria Čarna, Isaac G Onyango, Stanislav Katina, Dušan Holub, Jan Sebastian Novotny, Marketa Nezvedova, Durga Jha, Zuzana Nedelska, Valentina Lacovich, Thijs Vande Vyvere, Ruben Houbrechts, Krystine Garcia-Mansfield, Ritin Sharma, Victoria David-Dirgo, Martin Vyhnalek, Kateřina Texlova, Hernan Chaves, Nadine Bakkar, Lucia Pertierra, Mojmir Vinkler, Hana Markova, Jan Laczo, Kateřina Sheardova, Marcela Hortova-Kohoutkova, Jan Frič, Giancarlo Forte, Petr Kaňovsky, Silvie Belaškova, Jiři Damborsky, Jakub Hort, Nicholas T Seyfried, Robert Bowser, Gustavo Sevlever, Robert A Rissman, Richard A Smith, Marian Hajduch, Patrick Pirrotte, Zdenek Spacil, Eric B Dammer, Clara Limbäck-Stokin, Gorazd B Stokin. Alzheimers Dement. 2023 Aug;19(8):3537-3554.

doi: 10.1002/alz.12970. PMID: 36825691.

 

More Than 2% of Circulating Tumor Plasma Cells Defines Plasma Cell Leukemia-Like Multiple Myeloma. Tomas Jelinek, Renata Bezdekova, David Zihala, Tereza Sevcikova, Anjana Anilkumar Sithara, Lenka Pospisilova, Sabina Sevcikova, Petra Polackova, Martin Stork, Zdenka Knechtova, Ondrej Venglar, Veronika Kapustova, Tereza Popkova, Ludmila Muronova, Zuzana Chyra, Matous Hrdinka, Michal Simicek, Juan-Jose Garcés, Noemi Puig, Maria-Teresa Cedena, Artur Jurczyszyn, Jorge J Castillo, Miroslav Penka, Jakub Radocha, Maria Victoria Mateos, Jesús F San-Miguel, Bruno Paiva, Ludek Pour, Lucie Rihova, Roman Hajek. J Clin Oncol. 2023 Mar 1;41(7):1383-1392.

doi: 10.1200/JCO.22.01226. PMID: 36315921; PMCID: PMC9995102.

 

From fish to cells: Establishment of continuous cell lines from embryos of annual killifish Nothobranchius furzeri and N. kadleci. Kamila Součková, Matej Jasík, Iva Sovadinová, Alexandr Sember, Eliška Sychrová, Anna Konieczna, Vojtěch Bystrý, Iva Dyková, Radim Blažek, Karolína Lukšíková, Tomáš Pavlica, Marek Jankásek, Marie Altmanová, Jakub Žák, Adriana Zbončáková, Martin Reichard, Ondřej Slabý. Aquat Toxicol. 2023 Jun;259:106517.

doi: 10.1016/j.aquatox.2023.106517. PMID: 37087860.

 

Gemtuzumab ozogamicin plus midostaurin in conjunction with standard intensive therapy for FLT3- mutated acute myeloid leukemia patients - Czech center experience. Barbora Weinbergerová, Martin Čerňan, Tomáš Kabut, Lukáš Semerád, Natália Podstavková, Tomáš Szotkowski, Ivana Ježíšková, Jiří Mayer. Haematologica. 2023 Oct 1;108(10):2826-2829.

doi: 10.3324/haematol.2022.282263. PMID: 36815379; PMCID: PMC10542832.

 

Targeted treatment of severe vascular malformations harboring PIK3CA and TEK mutations with alpelisib is highly effective with limited toxicity. Martin Sterba, Petra Pokorna, Renata Faberova, Blanka Pinkova, Jarmila Skotakova, Anna Seehofnerova, Jan Blatny, Lucia Janigova, Olga Koskova, Hana Palova, Michal Mahdal, Lukas Pazourek, Petr Jabandziev, Ondrej Slaby, Peter Mudry, Jaroslav Sterba. Sci Rep. 2023 Jun 28;13(1):10499.

doi: 10.1038/s41598-023-37468-4. PMID: 37380669; PMCID: PMC10307862.

 

Desmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide. Petr Lapcik, Petr Sulc, Lucia Janacova, Katerina Jilkova, David Potesil, Pavla Bouchalova, Petr Müller, Pavel Bouchal Cell Mol Biol Lett. 2023 Aug 24;28(1):68.

doi: 10.1186/s11658-023-00481-6. PMID: 37620794; PMCID: PMC10464112.

 

Electrochemical biosensors for analysis of DNA point mutations in cancer research. Katerina Ondraskova, Ravery Sebuyoya, Ludmila Moranova, Jitka Holcakova, Petr Vonka, Roman Hrstka, Martin Bartosik. Anal Bioanal Chem. 2023 Mar;415(6):1065-1085.

doi: 10.1007/s00216-022-04388-7. PMID: 36289102.

 

Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor. Varadinkova S, Oralova V, Clarke M, Frampton J, Knopfova L, Lesot H, Bartos P, Matalova E. Front Cell Dev Biol. 2023 Aug 28;11:1168866.

doi: 10.3389/fcell.2023.1168866. PMID: 37701782; PMCID: PMC10493412.

 

In-depth analysis of biocatalysts by microfluidics: An emerging source of data for machine learning. Michal Vasina, David Kovar, Jiri Damborsky, Yun Ding, Tianjin Yang, Andrew deMello, Stanislav Mazurenko, Stavros Stavrakis, Zbynek Prokop. Biotechnol Adv. 2023 Sep;66:108171.

doi: 10.1016/j.biotechadv.2023.108171. PMID: 37150331.

 

Lysin (K)-specific demethylase 1 inhibition enhances proteasome inhibitor response and overcomes drug resistance in multiple myeloma. Cecilia Bandini, Elisabetta Mereu, Tina Paradzik, Maria Labrador, Monica Maccagno, Michela Cumerlato, Federico Oreglia, Lorenzo Prever, Veronica Manicardi, Elisa Taiana, Domenica Ronchetti, Mattia D'Agostino, Francesca Gay, Alessandra Larocca, Lenka Besse, Giorgio Roberto Merlo, Emilio Hirsch, Alessia Ciarrocchi, Giorgio Inghirami, Antonino Neri, Roberto Piva. Exp Hematol Oncol. 2023 Aug 10;12(1):71.

doi: 10.1186/s40164-023-00434-x. PMID: 37563685; PMCID: PMC10413620.

 

Optimized procedure for high-throughput transcriptome profiling of small extracellular vesicles isolated from low volume serum samples. Petra Vychytilova-Faltejskova, Sara Vilmanova, Lucie Pifkova, Tina Catela Ivković, Marie Mᶏdrzyk, Robin Jugas, Tana Machackova, Jan Kotoucek, Milana Sachlova, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Igor Kiss, Ondrej Slaby. Clin Chem Lab Med. 2023 Jul 31;62(1):157-167.

doi: 10.1515/cclm-2023-0610. PMID: 37505924.

 

pyCaverDock: Python implementation of the popular tool for analysis of ligand transport with advanced caching and batch calculation support. Ondrej Vavra, Jakub Beranek, Jan Stourac, Martin Surkovsky, Jiri Filipovic , Jiri Damborsky, Jan Martinovic, David Bednar. Bioinformatics. 2023 Aug 1;39(8):btad443.

doi: 10.1093/bioinformatics/btad443. PMID: 37471591; PMCID: PMC10397418.

 

SBILib: a handle for protein modeling and engineering. Patrick Gohl, Jaume Bonet, Oriol Fornes, Joan Planas-Iglesias, Narcís Fernandez-Fuentes, Baldo Oliva. Bioinformatics. 2023 Oct 3;39(10):btad613.

doi: 10.1093/bioinformatics/btad613. PMID: 37796837; PMCID: PMC10589914.

 

Tumor Cell-Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model. Merel van Gogh, Jesus F Glaus Garzon, Dilara Sahin, Lucia Knopfova, Petr Benes, Onur Boyman, Igor Jurisica, Lubor Borsig. Cancer Immunol Res. 2023 Oct 4;11(10):1432-1444.

doi: 10.1158/2326-6066.CIR-22-0912. PMID: 37478172; PMCID: PMC10548106.

 

Molecular portraits of colorectal cancer morphological regions. Eva Budinská, Martina Hrivňáková, Tina Catela Ivkovic, Marie Madrzyk, Rudolf Nenutil, Beatrix Bencsiková, Dagmar Al Tukmachi, Michaela Ručková, Lenka Zdražilová Dubská, Ondřej Slabý, Josef Feit, Mihnea-Paul Dragomir, Petra Borilova Linhartova, Sabine Tejpar, Vlad Popovici. Elife. 2023 Nov 13;12:RP86655.

doi: 10.7554/eLife.86655. PMID: 37956043; PMCID: PMC10642970.

 

MiR-4649-5p acts as a tumor-suppressive microRNA in triple negative breast cancer by direct interaction with PIP5K1C, thereby potentiating growth-inhibitory effects of the AKT inhibitor capivasertib. Katharina Jonas, Felix Prinz, Manuela Ferracin, Katarina Krajina, Barbara Pasculli, Alexander Deutsch, Tobias Madl, Beate Rinner, Ondrej Slaby, Christiane Klec, Martin Pichler. Breast Cancer Res. 2023 Oct 6;25(1):119.

doi: 10.1186/s13058-023-01716-2. PMID: 37803350; PMCID: PMC10559525.

 

Disclosing quantitative RT-PCR raw data during manuscript submission: a call for action. Andreas Untergasser, Jan Hellemans, Michael W Pfaffl, Jan M Ruijter, Maurice J B van den Hoff, Mihnea P Dragomir, Douglas Adamoski, Sandra Martha Gomes Dias, Rui Manuel Reis, Manuela Ferracin, Emmanuel Dias-Neto, Ian Marsh, Mikael Kubista, Muller Fabbri, Ajay Goel, Ondřej Slabý, Erik Knutsen, Baoqing Chen, Massimo Negrini, Koshi Mimori, Martin Pichler, Maria Papatriantafyllou, Simone Anfossi, Thomas D Schmittgen, Jim Huggett, Stephen Bustin, Jo Vandesompele, George A Calin; HEROIC (tHe initiativE gRoup On qRT dIsClosure) Consortium. Mol Oncol. 2023 May;17(5):713-717.

doi: 10.1002/1878-0261.13418. PMID: 36916500; PMCID: PMC10158759.

 

Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2. Gabriele Colozza, Heetak Lee, Alessandra Merenda, Szu-Hsien Sam Wu, Andrea Català-Bordes, Tomasz W Radaszkiewicz, Ingrid Jordens, Ji-Hyun Lee, Aileen-Diane Bamford, Fiona Farnhammer, Teck Yew Low, Madelon M Maurice, Vítězslav Bryja, Jihoon Kim, Bon-Kyoung Koo. Sci Adv. 2023 Nov 24;9(47):eadh9673.

doi: 10.1126/sciadv.adh9673. PMID: 38000028; PMCID: PMC10672176.

 

Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development. Marcos Gonzalez Lopez, Barbora Huteckova, Josef Lavicky, Nikodem Zezula, Vladislav Rakultsev, Vendula Fridrichova, Haneen Tuaima, Cita Nottmeier, Julian Petersen, Michaela Kavkova, Tomas Zikmund, Jozef Kaiser, Rupali Lav, Haza Star, Vítězslav Bryja, Petr Henyš, Miroslav Vořechovský, Abigail S Tucker, Jakub Harnos, Marcela Buchtova, Jan Krivanek. Sci Adv. 2023 Aug 2;9(31):eadi0482.

doi: 10.1126/sciadv.adi0482. PMID: 37531427; PMCID: PMC10396306.

 

High-dose aciclovir in CMV infection prophylaxis after allogeneic HSCT: a single-center long-term experience. Tomáš Kabut, Barbora Weinbergerová, František Folber, Martina Lengerová, Jiří Mayer. Bone Marrow Transplant. 2023 Nov;58(11):1229-1236.

doi: 10.1038/s41409-023-02081-6. PMID: 37612466; PMCID: PMC10622319.

 

Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY. Larry Mansouri, Birna Thorvaldsdottir, Lesley-Ann Sutton, Georgios Karakatsoulis, Manja Meggendorfer, Helen Parker, Ferran Nadeu, Christian Brieghel, Stamatia Laidou, Riccardo Moia, Davide Rossi, Mark Catherwood, Jana Kotaskova, Julio Delgado, Ana E Rodríguez-Vicente, Rocío Benito, Gian Matteo Rigolin, Silvia Bonfiglio, Lydia Scarfo, Mattias Mattsson, Zadie Davis, Ajay Gogia, Lata Rani, Panagiotis Baliakas, Hassan Foroughi-Asl, Cecilia Jylhä, Aron Skaftason, Inmaculada Rapado, Fatima Miras, Joaquín Martinez-Lopez, Javier de la Serna, Jesús María Hernández Rivas, Patrick Thornton, María José Larráyoz, María José Calasanz, Viktória Fésüs, Zoltán Mátrai, Csaba Bödör, Karin E Smedby, Blanca Espinet, Anna Puiggros, Ritu Gupta, Lars Bullinger, Francesc Bosch, Bárbara Tazón-Vega, Fanny Baran-Marszak, David Oscier, Florence Nguyen-Khac, Thorsten Zenz, Maria Jose Terol, Antonio Cuneo, María Hernández-Sánchez, Sarka Pospisilova, Ken Mills, Gianluca Gaidano, Carsten U Niemann, Elias Campo, Jonathan C Strefford, Paolo Ghia, Kostas Stamatopoulos, Richard Rosenquist. Leukemia. 2023 Feb;37(2):339-347.

doi: 10.1038/s41375-022-01802-y. PMID: 36566271; PMCID: PMC9898037.

 

Infrared Laser Desorption of Intact Nanoparticles for Digital Tissue Imaging. Marek Stiborek, Lenka Jindřichová, Stanislava Meliorisová, Antonín Bednařík, Vadym Prysiazhnyi, Jiří Kroupa, Pavel Houška, Barbora Adamová, Jarmila Navrátilová, Viktor Kanický, Jan Preisler. Anal Chem. 2022 Dec 27;94(51):18114-18120.

doi: 10.1021/acs.analchem.2c05216. PMID: 36514811.

 

Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery. Vladimír Procházka, Lukáš Lacina, Karel Smetana Jr, Martin Svoboda, Kateřina Skřivanová, Miroslava Beňovská, Jiří Jarkovský, Leoš Křen, Zdeněk Kala. World J Surg Oncol. 2023 Dec 14;21(1):384.

doi: 10.1186/s12957-023-03270-9. PMID: 38098074; PMCID: PMC10720211.

 

Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation. Nataliia Pavliuchenko, Iris Duric, Jarmila Kralova, Matej Fabisik, Frantisek Spoutil, Jan Prochazka, Petr Kasparek, Jana Pokorna, Tereza Skopcova, Radislav Sedlacek, Tomas Brdicka. Front Immunol. 2022 Dec 20;13:1035226.

doi: 10.3389/fimmu.2022.1035226. PMID: 36605205; PMCID: PMC9807597.

 

 

A patent review of cyclin-dependent kinase 7 (CDK7) inhibitors (2018-2022). Marketa Kovalová, Joseph Peter Baraka, Václav Mik, Radek Jorda, Lei Luo, Hao Shao, Vladimír Kryštof. Expert Opin Ther Pat. 2023 Feb;33(2):67-87.

doi: 10.1080/13543776.2023.2195547. PMID: 36975020

Active eosinophils regulate host defence and immune responses in colitis. Alessandra Gurtner, Costanza Borrelli, Ignacio Gonzalez-Perez, Karsten Bach, Ilhan E Acar, Nicolás G Núñez, Daniel Crepaz, Kristina Handler, Vivian P Vu, Atefeh Lafzi, Kristin Stirm, Deeksha Raju, Julia Gschwend, Konrad Basler, Christoph Schneider, Emma Slack, Tomas Valenta, Burkhard Becher, Philippe Krebs, Andreas E Moor, Isabelle C Arnold. Nature 2023, 615(7950):151-157.

doi: 10.1038/s41586-022-05628-7. PMID: 36509106

AMACR Expression is a Potential Diagnostic Marker in Apocrine Lesions of Breast, and is Associated with High Histologic Grade and Lymph Node Metastases in Some Invasive Apocrine Breast Cancers. Gabriel Lerner, Haiming Tang, Kamaljeet Singh, Reza Golestani, Samantha St Claire, Peter A Humphrey, Donald Lannin, Radoslav Janostiak, Malini Harigopal. Clin Breast Cancer. 2023 Feb;23(2):199-210.

doi: 10.1016/j.clbc.2022.11.012. PMID: 36577560

 

A-ring-fused pyrazoles of dihydrotestosterone targeting prostate cancer cells via the downregulation of the androgen receptor. Miroslav Peřina, Márton A Kiss, Gergo Motoyán, Eva Szczyrbová, Martin Eliáš, Vladimír Študent Jr, Daniela Kurfurstová, Markéta Kovalová, Lukáš Mada, Jan Bouchal, Eva Frank, Radek Jorda. Eur J Med Chem. 2023 Mar 5;249:115086.

doi: 10.1016/j.ejmech.2023.115086. PMID: 36682291

 

Cannabis-derived products antagonize platinum drugs by altered cellular transport. Tereza Buchtová, Lucie Beresova, Katarina Chromá, Tomáš Pluhacek, Tibor Beres, Dominika Kaczorova, Petr Tarkowski, Jiri Bartek, Martin Mistrík. Biomed Pharmacother. 2023 May 1;163:114801.

doi: 10.1016/j.biopha.2023.114801. PMID: 37137184

 

Circulating tumor nucleic acids: biology, release mechanisms, and clinical relevance. Pavel Stejskal, Hani Goodarzi, Josef Srovnal, Marián Hajdúch, Laura J vant Veer, Mark Jesus M Magbanua. Mol Cancer. 2023 Jan 21;22(1):15.

doi: 10.1186/s12943-022-01710-w. PMID: 36681803

 

Clinical lipidomics in the era of the big data. Aleš Kvasnička, Lukáš Najdekr, Dana Dobešová, Barbora Piskláková, Eliška Ivanovová, David Friedecký. Clin Chem Lab Med. 2023 Jan 4;61(4):587-598.

doi: 10.1515/cclm-2022-1105. PMID: 36592414  

 

Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia. Eleanor L Woodward, Minjun Yang, Larissa H Moura-Castro, Hilda van den Bos, Rebeqa Gunnarsson Linda Olsson-Arvidsson, Diana C J Spierings, Anders Castor, Nicolas Duployez, Marketa Zaliova, Jan Zuna, Bertil Johansson, Floris Foijer, Kajsa Paulsson. Nat Commun. 2023 Mar 25;14(1):1658.

doi: 10.1038/s41467-023-37356-5. PMID: 36966135; PMCID: PMC10039905

 

Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome. Adriana A de Jesus, Guibin Chen, Dan Yang, Tomas Brdicka, Natasha M Ruth, David Bennin, Dita Cebecauerova, Hana Malcova, Helen Freeman, Neil Martin, Karel Svojgr, Murray H Passo, Farzana Bhuyan, Sara Alehashemi, Andre T Rastegar, Katsiaryna Uss, Lela Kardava, Bernadette Marrero, Iris Duric, Ebun Omoyinmi, Petra Peldova, Chyi-Chia Richard Lee, David E Kleiner, Colleen M Hadigan, Stephen M Hewitt, Stefania Pittaluga, Carmelo Carmona-Rivera, Katherine R Calvo, Nirali Shah, Miroslava Balascakova, Danielle L Fink, Radana Kotalova, Zuzana Parackova, Lucie Peterkova, Daniela Kuzilkova, Vit Campr, Lucie Sramkova, Angelique Biancotto, Stephen R Brooks, Cameron Manes, Eric Meffre, Rebecca L Harper, Hyesun Kuehn, Mariana J Kaplan, Paul Brogan, Sergio D Rosenzweig, Melinda Merchant, Zuoming Deng, Anna Huttenlocher, Susan L Moir, Douglas B Kuhns, Manfred Boehm, Karolina Skvarova Kramarzova, Raphaela Goldbach-Mansky. Nat Commun. 2023 Mar 17;14(1):1502.

doi: 10.1038/s41467-023-36941-y. PMID: 36932076; PMCID: PMC10022554

 

Cytoplasmic Tail of MT1-MMP: A Hub of MT1-MMP Regulation and Function. Katerina Strouhalova, Ondřej Tolde, Daniel Rosel, Jan Brábek. Int J Mol Sci 2023 Mar 7;24(6):5068.

doi: 10.3390/ijms24065068. PMID: 36982142

 

Cytotoxicity evaluation of photosensitizer-conjugated hexagonal upconverting nanoparticles. Mykhailo Nahorniak, Viktoriia Oleksa, Taras Vasylyshyn, Ognen Pop-Georgievski, Eliška Rydvalová, Marcela Filipová, Daniel Horák. Nanomaterials 2023. Roč. 13, č. 9, č. článku 1535.

doi: 10.3390/nano13091535. PMCID: PMC10180129

 

Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors. Jan Skácel, Stefan Djukic, Ondřej Baszczyňski, Filip Kalčic, Tadeáš Bílek, Karel Chalupský, Jaroslav Kozák, Alexandra Dvořáková, Eva Tloušt’ová, Zuzana Král’ová, Markéta Šmídková, Jan Voldřich, Michaela Rumlová, Petr Pachl, Jiří Brynda, Tereza Vučková, Milan Fábry, Jan Snášel, Iva Pichová, Pavlína Řezáčová, Helena Mertlíková-Kaiserová, Zlatko Janeba. Journal of Medicinal Chemistry, 2023.

doi: 10.1021/acs.jmedchem.2c02097. PMID: 37134237

DiaPASEF proteotype analysis indicates changes in cell growth and metabolic switch induced by caspase-9 inhibition in chondrogenic cells. Petr Lapcik, Barbora Vesela, David Potesil, Katerina Dadakova, Martina Zapletalova, Petr Benes, Pavel Bouchal, Eva Matalova. Proteomics, 00, e2200408.

doi: 10.1002/pmic.202200408. PMID: 36960851

Engine shutdown: migrastatic strategies and prevention of metastases. Martina Raudenská, Kateřina Petrláková, Tamara Juriňáková, Jindřiška Leischner Fialová, Michaela Fojtů, Milan Jakubek, Daniel Rösel, Jan Brábek, Michal Masařík. Trends in Cancer 2023, 9(4), 293.

doi: 10.1016/j.trecan.2023.01.001. PMID: 36804341

 

Evaluation of linear versus star-like polymer anti-cancer nanomedicines in mouse models. Libor Kostka, Lenka Kotrchová, Eva Randárová, Carolina A. Ferreira, Iva Malátová, Hye Jin Lee, Aeli P. Olson, Jonathan W. Engle, Marek Kovář, Weibo Cai, Milada Šírová, Tomáš Etrych. Journal of Controlled Release. Roč. 353, January (2023), s. 549-562.

doi: 10.1016/j.jconrel.2022.11.060. PMID: 36470330

 

Expression of Selected miRNAs in Normal and Cancer-Associated Fibroblasts and in BxPc3 and MIA PaCa-2 Cell Lines of Pancreatic Ductal Adenocarcinoma. Václav Mandys, Alexey Popov, Robert Gürlich, Jan Havránek, Lucie Pfeiferová, Michal Kolář, Jana Vránová, Karel Smetana, Jr., Lukáš Lacina, Pavol Szabo. Int. J. Mol. Sci. 2023, 24(4), 3617.

doi: 10.3390/ijms24043617. PMID: 36835029

 

FoxP3 Expression in Tumor-Infiltrating Lymphocytes as Potential Predictor of Response to Immune Checkpoint Inhibitors in Patients with Advanced Melanoma and Non-Small Cell Lung Cancer. Peter Grell, Simona Borilova, Pavel Fabian, Iveta Selingerova, David Novak, Petr Muller, Igor Kiss, Rostislav Vyzula. Cancers 2023;15(6):1901.

doi: 10.3390/cancers15061901. PMID: 36980787; PMCID: PMC10047850

 

HPMA copolymer conjugated 5-aminolevulinic acid exhibits superior efficacy for photodynamic therapy with tumor-responsive and targeting properties. Rayhanul Islam, Kevin Kotalík, Vladimír Šubr, Shanghui Gao, Jian-Rong Zhou, Kazumi Yokomizo, Tomáš Etrych, Jun Fang. Nanomedicine: Nanotechnology, Biology and Medicine 2023. Roč. 48, č. článku 102636.

doi: 10.1016/j.nano.2022.102636. PMID: 36549553

Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7. Markéta Kovalová, Libor Havlíček, Stefan Djukic, Jana Škerlová, Miroslav Peřina, Tomáš Pospíšil, Eva Řezníčková, Pavlína Řezáčová, Radek Jorda, Vladimír Kryštof. Biomedicine & Pharmacotherapy, 2023, 161: 114492.

doi: 10.1016/j.biopha.2023.114492. PMID: 36931035

 

Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance. Andrea Kuzelova, Naoko Dupacova, Barbora Antosova, Sweetu Susan Sunny, Zbynek Kozmik, Jr., Jan Paces, Arthur I. Skoultchi, Tomas Stopka, and Zbynek Kozmik. 2023. Cells 12, no. 7: 1035.

doi: 10.3390/cells12071035. PMID: 37048108; PMCID: PMC10093269

 

Identification of AGR2 Gene-Specific Expression Patterns Associated with Epithelial-Mesenchymal Transition. Andrea Martisova, Lucia Sommerova, Adam Krejci, Iveta Selingerova, Tamara Kolarova, Filip Zavadil Kokas, Milos Holanek, Jan Podhorec, Tomas Kazda, Roman Hrstka. Int J Mol Sci. 2022 Sep 16;23(18):10845.

doi: 10.3390/ijms231810845. PMID: 36142758; PMCID: PMC9504245

 

Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN Complex. Barbora Otahalova, Zuzana Volkova, Jana Soukupova, Petra Kleiblova, Marketa Janatova, Michal Vocka, Libor Macurek, Zdenek Kleibl. Int J Mol Sci. 2023;24(6):5612.

doi: 10.3390/ijms24065612. PMID: 36982687

Long-term survival trends in solid cancers in the Nordic countries marking timing of improvements. Kari Jussi Hemminki, Asta Försti, Václav Liška, Anna Kanerva, Otto Hemminki, Akseli Hemminki. International Journal of Cancer 2023 May 1;152(9):1837-1846.

doi: 10.1002/ijc.34416. PMID: 36571455

Low Frequency of Cancer-Predisposition Gene Mutations in Liver Transplant Candidates with Hepatocellular Carcinoma. Klara Horackova, Sona Frankova, Petra Zemankova, Petr Nehasil, Marta Cerna, Magdalena Neroldova, Barbora Otahalova, Jan Kral, Milena Hovhannisyan, Viktor Stranecky, Tomas Zima, Marketa Safarikova, Marta Kalousova, Jan Novotny, Jan Sperl,  Marianna Borecka, Sandra Jelinkova, Michal Vocka, Marketa Janatova, Petra Kleiblova, Zdenek Kleibl, Milan Jirsa, Jana Soukupova. Cancers (Basel). 2023 Dec 29;15(1):201.

doi: 10.3390/cancers15010201. PMID: 36612198

MicroRNA Profiling of Self-Renewing Human Neural Stem Cells Reveals Novel Sets of Differentially Expressed microRNAs During Neural Differentiation In Vitro. Veronika Fedorová, Kateřina Amruz Černá, Jan Oppelt, Veronika Pospíšilová, Tomáš Bárta, Marek Mraz, Dáša Bohačiaková. Stem Cell Rev and Rep (2023).

doi: 10.1007/s12015-023-10524-2. PMID: 36918496

Molecular Design of 68Ga- and 89Zr-labeled Anticalin radioligands for PET-imaging of PSMA-positive tumors. Volker Morath, Corinna Brandt, Friedrich-Christian Deuschle, Claudia T. Mendler, Claudia T. Mendler, Birgit Blechert, Dominik Summer, Cyril Barinka, Clemens Decristoforo, Wolfgang A. Weber, Markus Schwaiger, Arne Skerra. Mol. Pharmaceutics 2023,20(5), 2490-2501.

doi: 10.1021/acs.molpharmaceut.2c01066. PMID: 37068305

Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone). Iryna Ivasechko, Andrii Lozynskyi, Julia Senkiv, Piotr Roszczecko, Yuliia Kozak, Nataliya Finiuk, Olga Kluyuchivka, Nataliya Kashchak, Nazar Manko, Zvenyslava Maslyak, Daylo Lesyk, Andriy Karkhut, Svyatoslav Polovkovych, Robert Czarnomysy, Olga Szewczyk, Andriy Kozytskiy, Olexandr Karpenko, Dmytro Khyluk, Andzej Gzella, Krzysztof Bielawski, Anna Bielawska, Petr Dzubak, Sona Gurska, Marian Hajduch, Rostyslav Stoika, Roman Lesyk. Eur J Med Chem. 2023 Apr 5;252:115304.

doi: 10.1016/j.ejmech.2023.115304. PMID: 37001390

Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2. Denise G O'Mahony, Susan J Ramus, Melissa C Southey, Nicola S Meagher, Andreas Hadjisavvas, Esther M John, Ute Hamann, Evgeny N Imyanitov, Irene L Andrulis, Priyanka Sharma, Mary B Daly, Christopher R Hake, Jeffrey N Weitzel, Anna Jakubowska, Andrew K Godwin, Adalgeir Arason, Anita Bane, Jacques Simard, Penny Soucy, Maria A Caligo, Phuong L Mai, Kathleen B M Claes, Manuel R Teixeira, Wendy K Chung, Conxi Lazaro, Peter J Hulick, Amanda E Toland, Inge Sokilde Pedersen; HEBON Investigators; Susan L Neuhausen, Ana Vega, Miguel de la Hoya, Heli Nevanlinna, Mallika Dhawan, Valentina Zampiga, Rita Danesi, Liliana Varesco, Viviana Gismondi, Valerio Gaetano Vellone, Paul A James, Ramunas Janavicius, Liene Nikitina-Zake, Finn Cilius Nielsen, Thomas van Overeem Hansen, Tanja Pejovic, Ake Borg, Johanna Rantala, Kenneth Offit, Marco Montagna, Katherine L Nathanson, Susan M Domchek, Ana Osorio, María J García, Beth Y Karlan; GEMO Study Collaborators; Anna De Fazio, David Bowtell; AOCS Group; Lesley McGuffog, Goska Leslie, Michael T Parsons, Thilo Dörk, Lisa-Marie Speith, Elizabeth Santana Dos Santos, Alexandre André B A da Costa, Paolo Radice, Paolo Peterlongo, Laura Papi, Christoph Engel, Eric Hahnen, Rita K Schmutzler, Barbara Wappenschmidt, Douglas F Easton, Marc Tischkowitz, Christian F Singer, Yen Yen Tan, Alice S Whittemore, Weiva Sieh, James D Brenton, Drakoulis Yannoukakos, Florentia Fostira, Irene Konstantopoulou, Jana Soukupova, Michal Vocka; CZECANCA Consortium; Georgia Chenevix-Trench, Paul D P Pharoah, Antonis C Antoniou, David E Goldgar, Amanda B Spurdle, Kyriaki Michailidou; Consortium of Investigators of Modifiers of BRCA1/2; Evidence-based Network for the Interpretation of Germline Mutant Alleles Consortium. Br J Cancer. 2023 Apr 19. Online ahead of print.

doi: 10.1038/s41416-023-02263-5. PMID: 37076566

Personal comorbidities and their subsequent risks for liver, gallbladder and bile duct cancers. Kari Jussi Hemminki, Kristina Sundquist, Jan Sundquist, Asta Försti, Václav Liška, Akseli Hemminki, Xinjun Li. International Journal of Cancer 2023 Mar 15;152(6):1107-1114.

doi: 10.1002/ijc.34308. PMID: 36196489

 

Perspectives in the Application of High, Medium, and Low Molecular Weight Oat β-d-Glucans in Dietary Nutrition and Food Technology—A Short Overview. Leonid Sushytskyi, Andriy Synytsya, Jana Čopíková, Pavol Lukáč, Lenka Rajsiglová, Paolo Tenti, and Luca E. Vannucci. Foods 2023, 12, no. 6: 1121.

doi: 10.3390/foods12061121. PMID: 36981048; PMCID: PMC10048208

Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres. Radka Storchova, Matous Palek, Natalie Palkova, Pavel Veverka, Tomas Brom, Ctirad Hofr, Libor Macurek. Nucleic Acids Research. 2023; 51(3):1154-1172.

doi: 10.1093/nar/gkac1269. PMID: 36651296

PPM1D activity promotes the replication stress caused by cyclin E1 overexpression. Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannik Kok, Sonbin Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek. Molecular Oncology. 2023 (E-pub ahead of print)

doi: 10.1002/1878-0261.13433. PMID: 37067201

Recent Advances in Methods for Circulating Tumor Cell Detection. Monika Vidlářová, Alona Řehulková, Pavel Stejskal, Andrea Prokopova, Hanus Slavik. Marián Hajdúch, Josef Srovnal. Int J Mol Sci. 2023 Feb 15;24(4):3902.

doi: 10.3390/ijms24043902. PMID: 36835311

Selectivity of Hydroxamate- and Difluoromethyloxadiazole-Based Inhibitors of Histone Deacetylase 6 In Vitro and in Cells. Jakub Ptacek, Ivan Snajdr, Jiri Schimer, Zsofia Kutil, Jana Mikesova, Petra Baranova, Barbora Havlinova, Werner Tueckmantel, Pavel Majer, Alan Kozikowski, Cyril Barinka. Int. J. Mol. Sci. 2023, 24, 4720.

doi: 10.3390/ijms24054720. PMID: 36902164

The emerging role of microtubules in invasion plasticity. Anna Legátová, Markéta Pelantová, Daniel Rösel, Jan Brábek, Aneta Škarková. Front Oncol. 2023 Feb 13;13:1118171.

doi: 10.3389/fonc.2023.1118171. PMID: 36860323; PMCID: PMC9969133

The KMT2A recombinome of acute leukemias in 2023. C Meyer, P Larghero, B Almeida Lopes, T Burmeister, D Gröger, R Sutton, N C Venn, G Cazzaniga, L Corral Abascal, G Tsaur, L Fechina, M Emerenciano, M S Pombo-de-Oliveira, T Lund-Aho, T Lundán, M Montonen, V Juvonen, J Zuna, J Trka, P Ballerini, H Lapillonne, V H J Van der Velden, E Sonneveld, E Delabesse, R R C de Matos, M L M Silva, S Bomken, K Katsibardi, M Keernik, N Grardel, J Mason, R Price, J Kim, C Eckert, L Lo Nigro, C Bueno, P Menendez, U Zur Stadt, P Gameiro, L Sedék, T Szczepański, A Bidet, V Marcu, K Shichrur, S Izraeli, H O Madsen, B W Schäfer, S Kubetzko, R Kim, E Clappier, H Trautmann, M Brüggemann, P Archer, J Hancock, J Alten, A Möricke, M Stanulla, J Lentes, A K Bergmann, S Strehl, S Köhrer, K Nebral, M N Dworzak, O A Haas, C Arfeuille, A Caye-Eude, H Cavé, R Marschalek. Leukemia. 2023 May;37(5):988-1005.

doi: 10.1038/s41375-023-01877-1. PMID: 37019990; PMCID: PMC10169636

Therapeutic Potential and Limitations of Curcumin as Antimetastatic Agent. Petr Dytrych, Zdeněk Kejík, Jan Hajduch, Robert Kaplánek, Kateřina Veselá, Kateřina Kučnirová, Markéta Skaličková, Anna Venhauerová, David Hoskovec, Pavel Martásek, Milan Jakubek. Biomedicine and Pharmacotherapy 2023,163, 114758.

doi: 10.1016/j.biopha.2023.114758. PMID: 37141738

Triazole-based estradiol dimers prepared via CuAAC from 17α-ethinyl estradiol with five-atom linkers causing G2/M arrest and tubulin inhibition. Michal Jurášek, Jiří Řehulka, Lenka Hrubá, Aleksandra Ivanová, Soňa Gurská, Olena Mokshna, Pavel Trousil, Lukáš Huml, Pavel Polischchuk Marián Hajdúch, Pavel B Drašar, Petr Džubák. Bioorg Chem. 2023 Feb; 131:106334.

doi: 10.1016/j.bioorg.2022.106334. PMID: 36592487

Tunable Multivalent Platform for Immune Recruitment to Lower Antigen Expressing Cancers. Benjamin P M Lake, Ryan G Wylie, Cyril Bařinka, Anthony F Rullo. Angew Chem Int Ed Engl 2023, 62(9).

doi: 10.1002/anie.202214659. PMID: 36577087

Developmental changes in iron metabolism and erythropoiesis in mice with human gain-of-function erythropoietin receptor. Barbora Kralova, Lucie Sochorcova, Jihyun Song, Ondrej Jahoda, Katarina Hlusickova Kapralova, Josef T Prchal, Vladimir Divoky, Monika Horvathova. Am J Hematol. 2022 Oct;97(10):1286-1299.

doi: 10.1002/ajh.26658. PMID: 35815815

Thiosemicarbazones Can Act Synergistically with Anthracyclines to Downregulate CHEK1 Expression and Induce DNA Damage in Cell Lines Derived from Pediatric Solid Tumors. Silvia Paukovčeková, Maria Krchniakova, Petr Chlapek, Jakub Neradil, Jan Škoda, Renata Veselská. Int J Mol Sci 2022 Aug 1;23(15):8549.

doi: 10.3390/ijms23158549. PMID: 35955683; PMCID: PMC9369312

Fully automated virtual screening pipeline of FDA-approved drugs using Caver Web. Miloš Musil, Andrej Ježík, Marie Jankůjová, Jan Štourač, Jakub Galgonek, Saltuk Mustafa Eyrilmez, Jiří Vondrášek, Jiří Damborský, David Bednář. Comput Struct Biotechnol J. 2022, Nov 17;20:6512-6518.

doi: 10.1016/j.csbj.2022.11.031. PMID: 36467577; PMCID: PMC9705369

Current methods for studying metastatic potential of tumor cells. Pavla Bouchalová, Pavel Bouchal. Cancer Cell Int. 2022 Dec 9;22(1):394.

doi: 10.1186/s12935-022-02801-w. PMID: 36494720; PMCID: PMC9733110

The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location. Ilon Liu, Li Jiang, Erik R Samuelsson, Sergio Marco Salas, Alexander Beck, Olivia A Hack, Daeun Jeong, McKenzie L Shaw, Bernhard Englinger, Jenna LaBelle, Hafsa M Mire, Sibylle Madlener, Lisa Mayr, Michael A Quezada, Maria Trissal, Eshini Panditharatna, Kati J Ernst, Jayne Vogelzang, Taylor A Gatesman, Matthew E Halbert, Hana Pálová, Petra Pokorná, Jaroslav Štěrba, Ondřej Slabý, Rene Geyeregger, Aaron Diaz, Izac J Findlay, Matthew D Dun, Adam Resnick, Mario L Suvà, David T W Jones, Sameer Agnihotri, Jessica Svedlund, Carl Koschmann, Christine Haberler, Thomas Czech, Irene Slavc, Jennifer A Cotter, Keith L Ligon, Sanda Alexandrescu, W K Alfred Yung, Isabel Arrillaga-Romany, Johannes Gojo, Michelle Monje, Mats Nilsson, Mariella G Filbin. Nat Genet. 2022 Dec;54(12):1881-1894.

doi: 10.1038/s41588-022-01236-3. PMID: 36471067; PMCID: PMC9729116

Electrochemical DNA biosensor coupled to LAMP reaction for early diagnostics of cervical precancerous lesions. Ravery Sebuyoya, Ludmila Moráňová, Nasim Izadi, Roman Hrstka, Milan Anton, Martin Bartošík. Biosensors and Bioelectronics: X Volume 12, December 2022, 100224.

doi: 10.1016/j.biosx.2022.100224.

Electrochemical biosensors for analysis of DNA point mutations in cancer research. Kateřina Ondrášková, Ravery Sebuyoya, Ludmila Moráňová, Jitka Holčáková, Petr Voňka, Roman Hrstka, Martin Bartošík. Anal Bioanal Chem. 2023, Mar;415(6):1065-1085.

doi: 10.1007/s00216-022-04388-7 PMID: 36289102

Modulating the pharmacokinetic profile of Actinium-225-labeled macropa-derived radioconjugates by dual targeting of PSMA and albumin. Falco Reissig, Kristof Zarschler, Zbyněk Nový, Miloš Petřík, Kateřina Bendová, Daniela Kurfürstová, Jan Bouchal, Marie Charlotte Ludik, Florian Brandt, Klaus Kopka, Marta Khoylou, Hans-Jürgen Pietzsch, Marián Hajdúch, Constantin Mamat. Theranostics 2022, Oct 17;12(17):7203-7215.

doi: 10.7150/thno.78043. PMID: 36438496; PMCID: PMC9691366

Characterization of drug effects on cell cultures from phase-contrast microscopy images. Denis Baručić, Sumit Kaushik, Jan Kybic, Jarmila Stanková, Petr Džubák, Marián Hajdúch.

Comput Biol Med 2022, Dec;151(Pt A):106171

doi: 10.1016/j.compbiomed.2022.106171. PMID: 36306582

Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway. Srđan Grušanović, Petr Daněk, Maria Kuzmina, Miroslava Kari Adamcová, Burócziová, Monika, Romana Mikyšková, Karolina Vaníčková, Slađana Kosanović, Jana Pokorná, Milan Reiniš, Tomáš Brdička, Meritxell Alberich Jordà. EMBO Rep. 2023, Jan 9;24(1):e54729.
doi: 10.15252/embr.202254729. PMID: 36341527; PMCID: PMC9827550

γ-Tubulin in microtubule nucleation and beyond. Vadym Sulimenko, Eduarda Dráberová, Pavel Dráber. Front Cell Dev Biol. 2022, Sep 1;10:880761.
doi: 10.3389/fcell.2022.880761. PMID: 36158181; PMCID: PMC9503634

Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics. Žofia Chrienová, David Ryšánek, Patrik Olekšák, Dorota Starý, Marek Bajda, Milan Reiniš, Romana Mikyšková, Ondřej Novotný, Rudolf Andrýs, Adam Skarka, Pavla Vašicová, Josef Novák, Martin Vališ, Kamil Kuča, Zdeněk Hodný, Eugenie Nepovimová. Front Aging Neurosci. 2022 Dec 6;14:1048260.
doi: 10.3389/fnagi.2022.1048260. PMID: 36561137; PMCID: PMC9767416

Involvement of Small Non-Coding RNA and Cell Antigens in Pathogenesis of Extramedullary Multiple Myeloma. Monika Vlachová, Jana Gregorová, Petra Vychytilová-Faltejsková, Natalia Anna Gabło, Lenka Radová, Lenka Pospíšilová, Martina Almáši, Martin Štork, Zdenka Knechtová, Jiří Minařík, Tereza Popková, Tomáš Jelínek, Roman Hájek, Luděk Pour, Lucie Říhová, Sabina Ševčíková. Int J Mol Sci. 2022, Nov 25;23(23):14765.
doi: 10.3390/ijms232314765. PMID: 36499093; PMCID: PMC9741227

Unexpected Heterogeneity of Newly Diagnosed Multiple Myeloma Patients with Plasmacytomas. Martin Štork, Sabina Ševčíková, Tomáš Jelínek, Jiří Minařík, Jakub Radocha, Tomáš Pika, Lenka Pospíšilová, Ivan Špička, Jan Štraub, Petr Pavlíček, Alexandra Jungová, Zdeňka Knechtová, Viera Sandecká, Vladimír Maisnar, Roman Hájek, Luděk Pour.
Biomedicines 2022, 10(10), 2535.
doi: 10.3390/biomedicines10102535. PMID: 36289797; PMCID: PMC9599767

More Than 2% of Circulating Tumor Plasma Cells Defines Plasma Cell Leukemia–Like Multiple Myeloma. Tomáš Jelínek, Renata Bezděková, David Žihala, Tereza Ševčíková, Anjana Anilkumar Sithara, Lenka Pospíšlová, Sabina Ševčíková, Petra Poláčková, Martin Štork, Zdeňka Knechtová, Ondřej Venglář, Veronika Kapustová, Tereza Popková, Ludmila Muroňová, Zuzana Chyra, Matouš Hrdinka, Michal Šimíček, Juan-Jose Garcés, Noemi Puig, Maria-Teresa Cedena, Artur Jurczyszyn, Jorge J Castillo, Miroslav Penka, Jakub Radocha, María Victoria Mateos, Jesús San Miguel, Bruno Paiva, Luděk Pour, Lucie Říhová, Roman Hájek. J Clin Oncol. 2022, Oct 31;JCO2201226.
doi: 10.1200/JCO.22.01226. PMID: 36315921

Distinct p53 phosphorylation patterns in chroniclymphocytic leukemia patients are reflected in theactivation of circumjacent pathways upon DNA damage. Veronika Mančíková, Michaela Pešová, Šárka Pavlová, Robert Helma, Kristýna Zavácká, Václav Hejret, Petr Taus, Jakub Hynšt, Karla Plevová, Jitka Malčíková, Šarka Pospíšilová. Mol. Oncol. 2023, Jan;17(1):82-97.
doi: 10.1002/1878-0261.13337. PMID: 36334078; PMCID: PMC9812841

Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells. Maria Krchniakova, Silvia Paukovčeková, Petr Chlapek, Jakub Neradil, Jan Škoda, Renata Veselská. Front Pharmacol. 2022 Sep 7;13:976955.
doi: 10.3389/fphar.2022.976955. PMID: 36160437; PMCID: PMC9490180

Disulfriam increases the efficiency of 5-fluorouracil in organotypic cultures of colorectal carcinoma. Michal Hendrych, Kamila Říhová, Barbora Adamová, Vojtěch Hradil, Marek Stiborek, Petr Vlček, Markéta Hermanová, Jana Vašíčková, Petr Beneš, Jan Šmarda, Viktor Kanický, Jan Preisler, Jarmila Navrátilová. Biomed Pharmacother 2022, Sep;153:113465.
doi: 10.1016/j.biopha.2022.113465. PMID: 36076577

SoluProtMutDB: A manually curated database of protein solubility changes upon mutations. Jan Velecký, Marie Hamšíková, Jan Šťourač, Miloš Musil, Jiří Damborský, David Bednář, Stanislav Mazurenko. Comput Struct Biotechnol J. 2022, Nov 9;20:6339-6347.
doi: 10.1016/j.csbj.2022.11.009. PMID: 36420168; PMCID: PMC9678803

Minimal residual disease in BCR: ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease. Jan Zuna, Lenka Hovorková, Justina Krotká, Amelie Koehrmann, Michela Bardini, Lucie Winkowská, Eva Froňková, Julia Alten, Rolf Koehler, Cornelia Eckert, Lisa Brizzolara, Marie Trková, Jan Stuchlý, Martin Zimmermann, Paola De Lorenzo, Maria Grazia Valsecchi, Valentino Conter, Jan Starý, Martin Schrappe, Andrea Biondi, Jan Trka, Markéta Žaliová, Giovanni Cazzaniga, Gunnar Cario.

Leukemia volume 36, pages 2793–2801 (2022).

doi: 10.1038/s41375-022-01668-0. PMID: 35933523

Long Non-Coding RNA and microRNA Interplay in Colorectal Cancer and Their Effect on the Tumor Microenvironment. Marie Rajtmajerová, Andriy Trailin, Václav Liška, Kari Jussi Hemminki, Filip Ambrozkiewicz. Cancers 2022, 14(21), 5450.

doi: 10.3390/cancers14215450. PMID: 36358867; PMCID: PMC9655812

Activated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role as a Potential Target for Future Therapies. Esraa Ali, Andriy Trailin, Filip Ambrozkiewicz, Václav Liška, Kari Jussi Hemminki. Int. J. Mol. Sci. 2022, 23(23), 15292.

doi: 10.3390/ijms232315292. PMID: 36499616; PMCID: PMC9741299

LACTB exerts tumor suppressor properties in ovarian cancer through regulation of Slug. Valentina Cutano, Jessica Marianne Ferreira Mendes, Sara Escudeiro-Lopes, Susana Machado, Judith Vinaixa Forner, Juan M Gonzales-Morena, Martin Převorovský, Viacheslav Zemlianski, Yuxiong Feng, Petra Králová Viziová, Andrea Hartmanová, Beáta Malčeková, Pavel Jakoubě, Sonia Iyer, Zuzana Kečkéšová. Life Sci Alliance. 2022 Nov 14;6(1):e202201510.

doi: 10.26508/lsa.202201510. PMID: 36375842; PMCID: PMC9664245

TROP2 Represents a Negative Prognostic Factor in Colorectal Adenocarcinoma and Its Expression Is Associated with Features of Epithelial–Mesenchymal Transition and Invasiveness. Jiří Švec, Monika Šťastná, Lucie Janečková, Dušan Hrčkulák, Martina Vojtěchová, Jakub Onhajzer, Vítězslav Kříž, Kateřina Galušková, Eva Šloncová, Jan Kubovčiak, Lucie Pfeiferová, Jan Hrudka, Radoslav Matěj, Petr Waldauf, Lukáš Havlůj, Michal Kolář, Vladimír Kořínek. Cancers (Basel) 2022, Aug 26;14(17):4137.

doi: 10.3390/cancers14174137. PMID: 36077674; PMCID: PMC9454662

FBXO38 Ubiquitin Ligase Controls Centromere Integrity via ZXDA/B Stability. Nikol Dibus, Vladimír Kořínek, Lukáš Čermák. Front Cell Dev Biol. 2022 Jun 23;10:929288.

doi: 10.3389/fcell.2022.929288. PMID: 35813202; PMCID: PMC9260856

NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on MRD-based protocol. Michael Svatoň, Aneta Skotnicová, Leona Řezníčková, Andrea Rennerová, Taťána Valová, Michaela Kotrová, Vincent H J van der Velden, Monika Brüggemann, Nikos Darzentas, Anton W Langerak, Jan Zuna, Jan Starý, Jan Trka, Eva Froňková. Blood (2023) 141 (5): 529–533.

doi: 10.1182/blood.2022017003. PMID: 36240445

Azulene hydrazide-hydrazones for selective targeting of pancreatic cancer cells. Tereza Brogyányi, Robert Kaplánek, Zdeněk Kejík, Božena Hosnedlová, Veronika Antonyová, Nikita Abramenko, Kateřina Veselá, Pavel Martásek, Martin Vokurka, Des R Richardson, Milan Jakubek. Biomedicine & Pharmacotherapy, 2022 Nov; 155:113736.

doi: 10.1016/j.biopha.2022.113736. PMID: 36156366

Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy. Natividad Alquezar-Artieda, Daniela Kužílková, Jennie Roberts, Katerina Hložková, Alena Pecinová, Petr Pecina, Martina Zwyrtková, Eliška Potůčková, Daniel Kavan, Ivana Hermanová, Markéta Žaliová, Petr Novák, Tomáš Mráček, Lucie Šrámková, Daniel A Tennant, Jan Trka, Júlia Starková. Blood Adv. 2022 Nov 18;bloodadvances.2021006431.

doi: 10.1182/bloodadvances.2021006431. PMID: 36399517

Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration. Jindriška Leischner Fialová, Kateřina Hönigová, Martina Raudenská, Lucie Mikšátková, Renata Zobalová, Jiří Navrátil, Jana Šmigová, Taraka Ramji Moturu, Tomáš Vicar, Jan Balvan, Kateřina Veselá, Nikita Abramenko, Zdeněk Kejík, Robert Kaplánek, Jaromír Gumulec, Daniel Rosel, Pavel Martásek, Jan Brábek. Jiří Neužil, Michal Masařík. Biomedicine & Pharmacotherapy, 2022 Oct; 154:113582.

doi: 10.1016/j.biopha.2022.113582. PMID: 36055111

Complex genetic and histopathological study of 15 patient-derived xenografts of aggressive lymphomas. Radek Jakša, Jana Karolová, Michael Svatoň, Dmitry Kazantsev, Martina Grajciarová, Eva Pokorná, Zbyněk Tonar, Magdalena Klánová, Lucie Winkowska, Diana Maláriková, Petra Vočková, Kristina Forsterová, Nicol Renešová, Alexandra Dolníková, Kristýna Nožičková, Pavel Dundr, Eva Froňková, Marek Trněný, Pavel Klener. Laboratory Investigation, 2022 Sep; 102(9):957-965.

doi: 10.1038/s41374-022-00784-w. PMID: 35488033; PMCID: PMC9420679

Non-Psychotropic Cannabinoids as Inhibitors of TET1 Protein. Veronika Antonyová, Zdeněk Kejík, Tereza Brogyanyi, Robert Kaplánek, Kateřina Veselá, Nikita Abramenko, Tomáš Ocelka, Michal Masařík, Adam Matkowski, Jakub Gburek, Renata Abel, Andrean Goede, Robert Preissner, Petr Novotný, Milan Jakubek. Bioorganic Chemistry, 2022 Jul; 124:105793.

doi: 10.1016/j.bioorg.2022.105793. PMID: 35462234

Targeting of the Mitochondrial TET1 Protein by Pyrrolo[3,2-b]pyrrole Chelators. Veronika Antonyová, Ameneh Tatar, Tereza Brogyányi, Zdeněk Kejík, Robert Kaplánek, Fréderic Vellieux, Nikita Abramenko, Alla Sinica, Jan Hajduch, Petr Novotný, Bettie Sue Masters, Pavel Martásek, Milan Jakubek. Int. J. Mol. Sci, 2022 Sep; 16;23(18):10850.

doi: 10.3390/ijms231810850. PMID: 36142763; PMCID: PMC9505425

G-CSF plus azacitidine versus azacitidine alone for patients with high-risk myelodysplastic syndrome: academic, open label, randomized trial. Tomáš Stopka, Lubomír Minařík, Nina Dusílková, Michal Pešta, Vojtěch Kulvait, Martin Špaček, Zuzana Zemanová, Marta Kalousová, Anna Jonášová. Blood Cancer Journal, volume 12, article number: 105 (2022).

doi: 10.1038/s41408-022-00698-2. PMID: 35798720; PMCID: PMC9262924

Combined Approach to Leukemic Differentiation Using Transcription Factor PU.1-Enhancing Agents. Petra Bašová, Helena Paszeková, Lubomír Minařík, Martina Dluhošová, Pavel Burda, Tomáš Stopka. Int. J. Mol. Sci, 2022, Jun; 16;23(12):6729.

doi: 10.3390/ijms23126729. PMID: 35743167; PMCID: PMC9224232

Quaternized Chitosan/Heparin Polyelectrolyte Multilayer Films for Protein Delivery. Tomasz Urbaniak, Gabriela S. García-Briones, Alexander Zhigunov, Sviatoslav Hladysh, Edyta Adrian, Volodymyr Lobaz, Tereza Krunclová, Olga Janoušková, Ognen Pop-Georgievski, Dana Kubies. Biomacromolecules 2022, 23, 11, 4734–4748.
doi: doi.org/10.1021/acs.biomac.2c00926. PMID: 36289568; PMCID: PMC9667497

New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity. Veronika Talianová, Zdeněk Kejík, Robert Kaplánek, Kateřina Veselá, Nikita Abramenko, Lukáš Lacina, Karolína Strnadová, Barbora Dvořánková, Pavel Martásek, Michal Masařík, Magdalena Houdová Megová, Petr Bušek, Jana Křížová, Lucie Zdražilová, Hana Hansíková, Erik Vlčák, Vlada Filimonenko, Aleksi Šedo, Karel Smetana Jr, Milan Jakubek. Pharmaceutics 2022, 14(8), 1712.
doi: 10.3390/pharmaceutics14081712. PMID: 36015338

Biomarker Dynamics and Long-Term Treatment Outcomes in Breast Cancer Patients with Residual Cancer Burden after Neoadjuvant Therapy. Milos Holanek, Iveta Selingerova, Pavel Fabian, Oldrich Coufal, Ondrej Zapletal, Katarina Petrakova, Tomas Kazda, Roman Hrstka, Alexandr Poprach, Maria Zvarikova, Ondrej Bilek, Marek Svoboda. Diagnostics 2022, 12(7), 1740.
doi: 10.3390/diagnostics12071740. PMID: 35885644; PMCID: PMC9318288

Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists. Zdeněk Vavřina, Pavla Perlíková, Nemanja Milisavljević, Florian Chevrier, Miroslav Smola, Joshua Smith, Milan Dejmek, Vojtěch Havlíček, Miloš Buděšínský, Radek Liboska, Lenka Vaneková, Jiří Brynda, Evzen Boura, Pavlína Řezáčová, Michal Hocek, and Gabriel Birkuš. J. Med. Chem.2022, 65, 20, 14082–14103.
doi: 10.1021/acs.jmedchem.2c01305. PMID: 36201304

Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments. David Lukac, Zuzana Machacova, Pavel Moudry. Life Sci Alliance. 2022 Sep 9;5(12):e202201560.
doi: 10.26508/lsa.202201560. PMID: 36260751; PMCID: PMC9463495

Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C-H Dibenzothiophenation and Negishi Coupling. Chao Yang, Lenka Poštová Slavětínská, Marianne Fleuti, Blanka Klepetářová, Michal Tichý, Soňa Gurská, Petr Pavliš, Petr Džubák, Marián Hajdúch, Michal Hocek. J. Am. Chem. Soc. 2022, 144, 42, 19437–19446.
doi: 10.1021/jacs.2c07517. PMID: 36245092

Preparation, In Vitro Affinity, and In Vivo Biodistribution of Receptor-Specific Ga-Labeled Peptides Targeting Vascular Endothelial Growth Factor Receptors. Pavel Barta, Rajamanikkam Kamaraj, Monika Kucharova, Zbynek Novy, Milos Petrik, Katerina Bendova, Marian Hajduch, Petr Pavek, Frantisek Trejtnar. Bioconjugate Chem. 2022, 33, 10, 1825–1836.
doi: 10.1021/acs.bioconjchem.2c00272. PMID: 36197842

Modulation of FLT3-ITD and CDK9 in acute myeloid leukaemia cells by novel proteolysis targeting chimera (PROTAC). Eva Řezníčková, Soňa Krajčovičová, Miroslav Peřina, Markéta Kovalová, Miroslav Soural, Vladimír Kryštof. Europen Journal of Medicinal Chem. 2022, 243, 114792.
doi: 10.1016/j.ejmech.2022.114792. PMID: 36191408

Triterpenoid pyrazines and pyridines – Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs. Jiří Hodoň, Ivo Frydrych, Zdeňka Trhlíková, Jan Pokorný, Lucie Borková, Sandra Benická, Martin Vlk, Barbora Lišková, Agáta Kubíčková, Martina Medvedíková, Martin Pisár, Jan Šarek, Viswanath Das, Anna Ligasová, Karel Koberna, Petr Džubák, Marián Hajdúch, Milan Urban. Europen Journal of Medicinal Chem. 2022, 243,114777.
doi: 10.1016/j.ejmech.2022.114777. PMID: 36174412

Mixture Effects of Tryptophan Intestinal Microbial Metabolites on Aryl Hydrocarbon Receptor Activity Aneta Vrzalová, Petra Pečinková, Peter Illés, Soňa Gurská, Petr Džubák, Martin Szotkowski, Marián Hajdúch, Sridhar Mani, Zdeněk Dvořák.
Int. J. Mol. Sci. 2022, 23 (18), 10825.
doi: 10.3390/ijms231810825. PMID: 36142735; PMCID: PMC9505659